Combustion synthesis of calcium phosphate constructs and powders doped with atoms, molecules, ions, or compounds

• US 10,118,827 B2
• Filed: 05/12/2014
• Issued: 11/06/2018
• Est. Priority Date: 05/10/2013
• Status: Active Grant

• Current Assignee: Nina L. Vollmer, Reed A. Ayers
• Original Assignee: Nina L. Vollmer, Reed A. Ayers
• Inventors: Ayers, Reed A., Vollmer, Nina L.
• Primary Examiner(s): Tate, Chris R
• Assistant Examiner(s): White, Douglas F
• Application Number:
  US14/275,641
• Publication Number:
  US 20140335197A1
• Time in Patent Office: 1,639 Days
• Field of Search: None
• CPC Class Codes: A61L 2300/102 Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/12 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: B01D 39/2068 Other inorganic materials, e.g. ceramics
• CPC Class Codes: C01B 25/32 Phosphates of magnesium, calcium, strontium, or barium

Abstract

The invention relates to a synthetic bone material and a process for making the same. The synthetic bone material may comprise multiple phases of calcium phosphate. Another aspect of the invention is a porous filter, and the method of making the same, and wherein the porous filter is substantially similar to the process for forming the synthetic bone material.

Claims

1. A method of producing a synthetic bone graft material, comprising:

mixing a calcium source and a phosphorus source to form a mixture, wherein the calcium source is selected from the group consisting of calcium oxide, calcium carbonate, calcium hydroxide, calcium fluoride, calcium nitrate, and combinations thereof, and wherein the phosphate source is selected from the group consisting of phosphorous pentoxide, phosphate (PO₄³⁻

), pyrophosphate, compounds thereof, and combinations thereof;

forming the mixture into a pellet; and

providing an ignition source to the pellet in an inert atmosphere to form the synthetic bone graft material, wherein an ignition temperature is less than about 100°

C.

2. The method of claim 1, wherein a material of the synthetic bone graft material comprises at least one calcium orthophosphate.

3. The method of claim 1, wherein the mixture comprises:

between about 0.5 to about 0.6 parts of the calcium source; and

between about 0.4 to about 0.5 parts of the phosphorous source.

4. The method of claim 1, wherein a ratio of the calcium source to phosphorous source in the mixture is about 0.54:

about 0.46.

5. The method of claim 1, wherein the mixing occurs in air.

6. The method of claim 1, wherein the mixing occurs in an inert environment, and wherein an inert gas of the inert environment is selected from the group consisting of argon, nitrogen, helium, and combinations thereof.

7. The method of claim 1, further comprising at least one additive of collagen, immunofluorescence label, alginate, chitosan coatings, BMPs, VEGF, allograft bone, xenograft bone, tissue and protein.

8. The method of claim 1, wherein the ignition source is at least one of a laser, a hot wire, an oven, a furnace, a flame, a torch, Joule heating, a hot press, a chemical catalyst, a chemical reaction and combinations thereof.

9. The method of claim 1, wherein the calcium source is a powder.

10. The method of claim 1, wherein the phosphate source is a powder.

11. The method of claim 1, wherein the calcium source is the calcium oxide, and wherein the phosphorus source is the phosphorous pentoxide.

12. The method of claim 1, further comprising heating the synthetic bone graft material at a temperature of between about 25°

C. and 1300°

C.

13. The method of claim 1, wherein a force applied to the mixture to form the pellet is between about 1 psi and about 80 psi.

14. The method of claim 1, wherein the mixture is pressed into a mold to form the pellet.

15. The method of claim 14, wherein a load of less than about 5000 metric tons of pressure is applied to the mold.

16. The method of claim 1, further comprising mixing the mixture with a dopant.

17. The method of claim 16, wherein the dopant is at least one of Mg, Sr, Sn, silver, gold, copper, zinc, and silver nitrate.

18. The method of claim 16, wherein the dopant is an antimicrobial agent.

19. The method of claim 1, further comprising mixing the calcium source and the phosphorous source with a dopant in an inert environment.

20. The method of claim 19, wherein the mixture comprises:

between about 50% by weight and about 60% by weight of the calcium source;

between about 40% by weight and about 50% by weight of the phosphorous source; and

between about 0.005% by weight and about 30% by weight of the dopant.