Systems for isolating and using clinically safe adipose derived regenerative cells
First Claim
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1. An automated system for separating and concentrating regenerative cells from tissue comprising:
- a collection chamber, which is configured to receive;
(1) tissue removed from a subject; and
(2) disaggregation agents, such that said disaggregation agents may be added to said tissue in an aseptic manner, and configured to separate said regenerative cells from the tissue;
a processing chamber connected to the collection chamber to receive disaggregated tissue from the collection chamber, wherein the processing chamber is coupled to the collection chamber via a conduit;
a centrifugation device which can connect to the processing chamber, wherein the centrifugation device is configured to concentrate regenerative cells from the disaggregated tissue present in the processing chamber;
a programmable processing device capable of communication with and controlling the collection chamber, the processing chamber, the centrifugation device and associated connections; and
an optical sensor along the conduit leading out of the collection chamber.
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Abstract
Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
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Citations
20 Claims
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1. An automated system for separating and concentrating regenerative cells from tissue comprising:
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a collection chamber, which is configured to receive;
(1) tissue removed from a subject; and
(2) disaggregation agents, such that said disaggregation agents may be added to said tissue in an aseptic manner, and configured to separate said regenerative cells from the tissue;a processing chamber connected to the collection chamber to receive disaggregated tissue from the collection chamber, wherein the processing chamber is coupled to the collection chamber via a conduit; a centrifugation device which can connect to the processing chamber, wherein the centrifugation device is configured to concentrate regenerative cells from the disaggregated tissue present in the processing chamber; a programmable processing device capable of communication with and controlling the collection chamber, the processing chamber, the centrifugation device and associated connections; and an optical sensor along the conduit leading out of the collection chamber. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification