Optoacoustic image mapping of tissue temperature
First Claim
1. An imaging system for visualization and accurate mapping of temperature distribution in absolute values in the region of interest and anatomical structures of live human or animal tissue independently on spatial distribution of the optical fluence in the body and independently on spatial distribution of the tissue optical properties, comprising:
- an optoacoustic imaging module that uses pulsed optical illumination at a preferred wavelength about 795 nm to about 805 nm or about 1300 nm to about 1305 nm;
an ultrasound imaging module having an ultrasonic probe communicably connected to an electronics system that also serves as a probe and to an electronics system for the optoacoustic imaging module and is configured to emit and to detect ultrasonic waves in an ultrasound imaging mode and to detect optoacoustic signals of thermal conditions dependent optoacoustic response of tissue in an optoacoustic imaging mode;
an image processing and calibration module connected to the optoacoustic imaging module and to the ultrasound imaging module and configured to generate an image co-registered in space and time from an image generated of the temperature distribution and an image generated of the anatomical structures of the live human or animal tissues;
an image display module configured to display the co-registered image;
a therapeutic module configured to apply a thermal treatment to the live human or animal tissue and to monitor and guide thermal therapy procedures therewithin; and
an operating and controlling module electronically connected with said image processing module and configured to control and manipulate at least one of the modules of the imaging system.
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Accused Products
Abstract
Provided herein are system and methods for monitoring and guiding thermal therapy procedures within a human or animal tissue. The system comprises a therapeutic module configured to apply thermal treatment to a subject; an ultrasound imaging module; an optoacoustic imaging module; a processing module connected to both ultrasound and optoacoustic based imaging module; and an operating controlling module connected with said processing module and configured to manipulate at least one of said therapeutic module, ultrasound imaging module or optoacoustic imaging module. The calibration method is able to eliminate the inconsistency of optoacoustic based temperature measurements caused by sample-to-sample and spatial variations of Gruneisen parameter for different tissues. The method for temperature-structure imaging is able to generate both two dimensional and three dimensional co-registered structure and temperature images for the tissues inside a region of interest of a subject.
6 Citations
16 Claims
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1. An imaging system for visualization and accurate mapping of temperature distribution in absolute values in the region of interest and anatomical structures of live human or animal tissue independently on spatial distribution of the optical fluence in the body and independently on spatial distribution of the tissue optical properties, comprising:
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an optoacoustic imaging module that uses pulsed optical illumination at a preferred wavelength about 795 nm to about 805 nm or about 1300 nm to about 1305 nm; an ultrasound imaging module having an ultrasonic probe communicably connected to an electronics system that also serves as a probe and to an electronics system for the optoacoustic imaging module and is configured to emit and to detect ultrasonic waves in an ultrasound imaging mode and to detect optoacoustic signals of thermal conditions dependent optoacoustic response of tissue in an optoacoustic imaging mode; an image processing and calibration module connected to the optoacoustic imaging module and to the ultrasound imaging module and configured to generate an image co-registered in space and time from an image generated of the temperature distribution and an image generated of the anatomical structures of the live human or animal tissues; an image display module configured to display the co-registered image; a therapeutic module configured to apply a thermal treatment to the live human or animal tissue and to monitor and guide thermal therapy procedures therewithin; and an operating and controlling module electronically connected with said image processing module and configured to control and manipulate at least one of the modules of the imaging system. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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Specification