Passive detection of pulse

• US 10,123,727 B2
• Filed: 06/30/2017
• Issued: 11/13/2018
• Est. Priority Date: 08/29/2014
• Status: Active Grant

• Current Assignee: Verily Life Sciences LLC (Alphabet Inc.)
• Original Assignee: Verily Life Sciences LLC (Alphabet Inc.)
• Inventors: Wiser, Robert Francis, Otis, Brian
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US15/638,503
• Publication Number:
  US 20170296111A1
• Time in Patent Office: 501 Days
• CPC Class Codes: A61B 2560/0214 of power generation or supply
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/02427 Details of sensor
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/14555 specially adapted for the eye fundus
• CPC Class Codes: A61B 5/6821 Eye
• CPC Class Codes: G02B 1/043 Contact lenses
• CPC Class Codes: H05K 999/99 dummy group

Abstract

A body-mountable light sensing device includes a photodiode configured to receive light from a portion of subsurface vasculature and electronics configured to operate the photodiode to measure the received light. The electronics include a photodiode voltage source configured to reverse bias the photodiode, a current mirror, and a sigma-delta modulator configured to generate a digital output related to the received light and having a high resolution while using low power. The digital output could be used to determine a pulse rate or other properties of blood in the portion of subsurface vasculature by detecting absorption of ambient light by blood in the portion of subsurface vasculature. Components of the body-mountable device could be embedded in a polymeric material configured for mounting to a surface of an eye. The digital output and/or related information could be wirelessly communicated by the body-mountable device.

Claims

1. A body-mountable device comprising:

a photodiode;

a photodiode voltage source, wherein the photodiode voltage source applies a voltage to the photodiode such that the photodiode is reverse biased, wherein a photodiode current through the photodiode is related to light received from a portion of subsurface vasculature;

a current-mode digital-to-analog converter (DAC), wherein the current-mode DAC sources or sinks a DAC current;

a current mirror, wherein the current mirror has an input current path and an output current path, wherein the current mirror provides an output current in the output current path that is related to an input current in the input current path, wherein the photodiode and current-mode DAC are connected in parallel to the input current path of the current mirror such that the input current is related to the photodiode current and DAC current; and

output electronics coupled to the output current path of the current mirror, wherein the output electronics provides a digital output related to the output current in the output current path of the current mirror.

2. The body-mountable device of claim 1, wherein the body-mountable device further comprises:

an antenna, wherein the antenna is operable to indicate a signal related to the digital output.

3. The body-mountable device of claim 1, wherein the photodiode is positioned to detect light received from the portion of subsurface vasculature when the body-mountable device is mounted to a body surface.

4. The body-mountable device of claim 3, wherein the photodiode current through the photodiode is related to an intensity of the light received from the portion of subsurface vasculature within a first range of wavelengths, wherein the body-mountable device further includes a photodetector that can detect an intensity of light received from the portion of subsurface vasculature within a second range of wavelengths, and wherein the intensity of the light detected by the photodiode and the intensity of the light detected by the photodetector are related to an oxygen saturation of blood in the portion of subsurface vasculature.

5. The body-mountable device of claim 3, wherein the body-mountable device comprises a shaped polymeric material, wherein the shaped polymeric material has a surface configured to be removably mounted on an eye.

6. The body-mountable device of claim 5, wherein the photodiode is disposed on a substrate in the polymeric material such that the portion of subsurface vasculature is a portion of vasculature of the eye when the surface is mounted on the eye.

7. The body-mountable device of claim 5, wherein the photodiode is disposed on a substrate in the polymeric material such that the portion of subsurface vasculature is a portion of vasculature of an eyelid of the eye when the surface is mounted on the eye and the eyelid is at least partially closed over the eye.

8. The body-mountable device of claim 3, wherein the photodiode current through the photodiode is related to an intensity of the light received from the portion of subsurface vasculature, and wherein the intensity of the light is related to a volume of blood in the subsurface vasculature.

9. The body-mountable device of claim 1, wherein the current mirror comprises a first transistor and a second transistor, wherein the first transistor is a part of the photodiode voltage source and is electronically connected between a voltage source and the photodiode, wherein the photodiode voltage source is configured to operate the first transistor by applying a control signal to a control terminal of the first transistor such that a voltage across the photodiode is substantially equal to a specified voltage, wherein the second transistor is electronically connected between the voltage source and the output electronics, and wherein the control signal is additionally applied to a control terminal of the second transistor.

10. The body-mountable device of claim 1, wherein the output electronics comprises a sigma-delta modulator.

11. The body-mountable device of claim 10, wherein the sigma-delta modulator comprises:

a capacitor, wherein the capacitor is coupled to the output current path of the current mirror;

a switched current sink, wherein the switched current sink can be operated to discharge a specified current from the capacitor; and

a comparator, wherein the comparator compares a voltage across the capacitor to a specified reference voltage, wherein the comparator generates a digital pulse when the voltage across the capacitor is greater than the specified reference voltage, and wherein the switched current sink is operated by the digital pulses generated by the comparator such that the switched current sink discharges the capacitor by a specified amount for each generated digital pulse.

12. The body-mountable device of claim 1, further comprising an antenna, wherein the antenna is operable to receive radio frequency energy to power the body-mountable device.

13. A method, comprising:

receiving, by a photodiode in a body-mountable device, light from a portion of sub surface vasculature;

applying, by a photodiode voltage source in the body-mountable device, a voltage to the photodiode such that the photodiode is reverse biased, wherein a photodiode current through the photodiode is related to the light received from the portion of subsurface vasculature;

providing, by a current-mode digital-to-analog converter (DAC) in the body-mountable device, a DAC current;

providing, by a current mirror in the body-mountable device, an output current in an output current path of the current mirror, wherein the output current is related to an input current in an input current path of the current mirror, and wherein the photodiode and current-mode DAC are connected in parallel to the input current path of the current mirror such that the input current is related to the photodiode current and DAC current; and

generating a digital output related to the output current in the output current path of the current mirror.

14. The method of claim 13, further comprising:

determining a property of blood in the portion of subsurface vasculature based on the generated digital output.

15. The method of claim 14, wherein the photodiode current through the photodiode is related to an intensity of the light received from the portion of subsurface vasculature within a first range of wavelengths, wherein the body-mountable device further includes a photodetector that can detect an intensity of light received from the portion of subsurface vasculature within a second range of wavelengths, wherein the method further includes operating the photodetector to detect the intensity of light received from the portion of subsurface vasculature within the second range of wavelengths, and wherein determining the property of blood in the portion of subsurface vasculature based on the generated digital output comprises determining an oxygen saturation of blood in the portion of subsurface vasculature based on the generated digital output and the intensity of light detected using the photodetector.

16. The method of claim 13, wherein the photodiode current through the photodiode is related to an intensity of light received from the portion of subsurface vasculature, wherein the intensity of the light received from the portion of subsurface vasculature is related to a volume of the blood in the subsurface vasculature, further comprising:

determining the volume of blood in the portion of subsurface vasculature based on the generated digital output a plurality of times at a plurality of respective points in time to generate a plurality of determined volumes of blood in the portion of subsurface vasculature; and

determining a property of blood flow in the portion of subsurface vasculature based on the plurality of determined volumes of blood in the portion of subsurface vasculature.

17. The method of claim 13, wherein the body-mountable device further comprises an antenna, further comprising:

indicating, using the antenna, a wireless signal related to the digital output.

18. The method of claim 17, wherein the indicating comprises reflecting a radio-frequency signal received by the antenna.

19. The method of claim 13, wherein the body-mountable device further comprises an antenna, further comprising:

using a radio-frequency signal received by the antenna to power the body-mountable device.