Tissue thickness compensator comprising controlled release and expansion
First Claim
1. A tissue thickness compensator comprising a tubular element, wherein the tubular element comprises:
- a first layer comprising a first biocompatible material sealingly enclosed in a water impermeable material; and
a second layer comprising a second biocompatible material comprising at least one encapsulation;
wherein the first biocompatible material comprises a temperature activatable precursor, wherein the temperature activatable precursor is activatable between an inactive state and an active state, and wherein the first biocompatible material expands when contacted with a fluid.
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Abstract
A tissue thickness compensator may generally comprise a first layer comprising a first biocompatible material sealingly enclosed in a water impermeable material and a second layer comprising a second biocompatible material comprising at least one encapsulation, wherein the first biocompatible material expands when contacted with a fluid. The tissue thickness compensator may comprise a haemostatic agent, an anti-inflammatory agent, an antibiotic agent, anti-microbial agent, an anti-adhesion agent, an anti-coagulant agent, a medicament, and/or pharmaceutically active agent. The encapsulation may comprise a biodegradable material to degrade in vivo and/or in situ. The tissue thickness compensator may comprise a hydrogel. The reaction product may comprise a fluid-swellable composition. Articles of manufacture comprising the tissue thickness compensator and methods of making and using the tissue thickness compensator are also described.
3866 Citations
18 Claims
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1. A tissue thickness compensator comprising a tubular element, wherein the tubular element comprises:
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a first layer comprising a first biocompatible material sealingly enclosed in a water impermeable material; and a second layer comprising a second biocompatible material comprising at least one encapsulation; wherein the first biocompatible material comprises a temperature activatable precursor, wherein the temperature activatable precursor is activatable between an inactive state and an active state, and wherein the first biocompatible material expands when contacted with a fluid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A tissue thickness compensator comprising a tubular element, wherein the tubular element comprises:
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an inner layer comprising a temperature activatable hydrogel precursor impregnated with at least one of a haemostatic agent, an anti-inflammatory agent, an antibiotic agent, anti-microbial agent, an anti-adhesion agent, an anti-coagulant agent, a medicament, and a pharmaceutically active agent; and an outer layer comprising a water impermeable material sealingly enclosing the inner layer; wherein the temperature activatable hydrogel precursor is activatable between an inactive state and an active state prior to being implanted, and wherein the temperature activatable hydrogel precursor expands when contacted with at least one of water, saline, and a bodily fluid. - View Dependent Claims (18)
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Specification