Vascular remodeling device

• US 10,123,804 B2
• Filed: 06/24/2016
• Issued: 11/13/2018
• Est. Priority Date: 05/11/2011
• Status: Active Grant

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Covidien LP (Medtronic Plc)
• Inventors: Cam, Anh, Losordo, Michael, Ma, Jianlu, Zhao, Xiaoling
• Primary Examiner(s): Rosen, Eric
• Assistant Examiner(s): Igboko, Chima
• Application Number:
  US15/192,150
• Publication Number:
  US 20160302797A1
• Time in Patent Office: 872 Days
• CPC Class Codes: A61B 17/12031 complete occlusion
• CPC Class Codes: A61B 17/12118 for positioning in conjunction with a stent
• CPC Class Codes: A61B 17/1214 Coils or wires
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/844 folded prior to deployment
• CPC Class Codes: A61F 2/86 Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2/95 Instruments specially adapted for placement or removal of stents or stent-grafts
• CPC Class Codes: A61F 2/954 for placing stents or stent-grafts in a bifurcation
• CPC Class Codes: A61F 2/966 with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
• CPC Class Codes: A61F 2002/077 having means to fill the space between stent-graft and aneurysm wall, e.g. a sleeve
• CPC Class Codes: A61F 2002/821 Ostial stents
• CPC Class Codes: A61F 2002/823 Stents, different from stent-grafts, adapted to cover an aneurysm
• CPC Class Codes: A61F 2230/0076 ellipsoidal or ovoid
• CPC Class Codes: A61F 2240/001 Designing or manufacturing processes
• CPC Class Codes: A61F 2250/0039 differing in diameter
• CPC Class Codes: Y10T 29/4998 Combined manufacture including applying or shaping of fluent material

Abstract

Described herein are flexible implantable devices or stents that can conform to the shape of vessels of the neurovasculature. In some embodiments, the devices can direct blood flow within a vessel away from an aneurysm or limit blood flow to the aneurysm. In some embodiments, a vascular remodeling device includes a first section and a protruding section. During deployment, the device expands from a compressed configuration to an expanded configuration. The first section anchors the device in an afferent vessel and/or in an efferent vessel of a bifurcation and the protruding section is positioned in the junction of the bifurcation having an aneurysm and across the neck of the aneurysm or at least partially within the aneurysm.

Claims

1. A method of treating an aneurysm at a junction of a bifurcation having an afferent vessel and first and second efferent vessels, the method comprising:

anchoring, in the first efferent vessel, a distal section of a stent while in an expanded configuration;

anchoring, in the afferent vessel, a proximal section of the stent while in the expanded configuration; and

positioning a protruding section of the stent while in the expanded configuration to abut an ostium of the aneurysm on a side of the aneurysm that is adjacent to the second efferent vessel, wherein, while in the expanded configuration, a maximum cross-sectional dimension of the protruding section is greater than a maximum cross-sectional dimension of the proximal section and a maximum cross-sectional dimension of the distal section,

wherein the stent comprises filaments, and at least a portion of the protruding section has a lower filament density than other portions of the protruding section to allow perfusion to the second efferent vessel.

2. The method of claim 1, further comprising positioning the protruding section to abut the ostium of the aneurysm on a side of the aneurysm that is adjacent to the first efferent vessel.

3. The method of claim 1, wherein the aneurysm is located between the first and second efferent vessels.

4. The method of claim 1, wherein the proximal section defines a proximal lumen, the distal section defines a distal lumen, and the protruding section defines an intermediate lumen, and wherein, after the positioning, the proximal, intermediate, and distal lumens provide a substantially unobstructed path for fluid flow from the afferent vessel to the first efferent vessel and a strut pattern of the protruding section permits fluid flow to the second efferent vessel.

5. The method of claim 1, wherein at least one of the proximal, distal, and protruding sections is self-expanding.

6. The method of claim 1, further comprising inserting embolic material into the aneurysm.

7. The method of claim 1, wherein, while in the expanded configuration, first cells of the proximal section and/or the distal section have a first cell size that is substantially equal to a second expanded cell size of the second cells of the protruding section.

8. The method of claim 1, wherein the protruding section has a strut pattern that is substantially the same as a strut pattern of the proximal section and/or the distal section.

9. The method of claim 1 wherein the protruding section extends around only a portion of the circumference of the stent.

10. A method of treating an aneurysm at a junction of a bifurcation having an afferent vessel and first and second efferent vessels, the method comprising:

providing a stent in a compressed configuration within a catheter, the stent comprising (i) a proximal section, (ii) a distal section; and

(iii) a protruding section, between the proximal and distal sections, and wherein the stent comprises filaments, and at least a portion of the protruding section has a lower filament density than other portions of the protruding section to allow perfusion to the second efferent vessel;

expanding the stent from the compressed configuration to an expanded configuration out of the catheter, the expanding comprising;

anchoring, in the first efferent vessel, the distal section;

anchoring, in the afferent vessel, the proximal section; and

positioning the protruding section to abut an ostium of the aneurysm on a side of the aneurysm that is adjacent to the second efferent vessel, wherein, while in the expanded configuration, a maximum cross-sectional dimension of the protruding section is greater than a maximum cross-sectional dimension of the proximal section and a maximum cross-sectional dimension of the distal section.

11. The method of claim 10, wherein the expanding further comprises positioning the protruding section to abut the ostium of the aneurysm on a side of the aneurysm that is adjacent to the first efferent vessel.

12. The method of claim 10, wherein the aneurysm is located between the first and second efferent vessels.

13. The method of claim 10, wherein the proximal section defines a proximal lumen, the distal section defines a distal lumen, and the protruding section defines an intermediate lumen, and wherein, after the expanding, the proximal, intermediate, and distal lumens provide a substantially unobstructed path for fluid flow from the afferent vessel to the first efferent vessel and a strut pattern of the protruding section permits fluid flow to the second efferent vessel.

14. The method of claim 10, wherein at least one of the proximal, distal, and protruding sections self-expands during the expanding.

15. The method of claim 10, further comprising inserting embolic material into the aneurysm.

16. The method of claim 10, wherein the protruding section has a strut pattern that is substantially the same as a strut pattern of the proximal section and/or the distal section.

17. The method of claim 10 wherein the protruding section extends around only a portion of the circumference of the stent.

18. A method of treating an aneurysm at a junction of a bifurcation having an afferent vessel and first and second efferent vessels, the method comprising:

providing a stent in a compressed configuration within a catheter, the stent comprising (i) a proximal section, (ii) a distal section; and

(iii) a protruding section, between the proximal and distal sections;

expanding the stent from the compressed configuration to an expanded configuration out of the catheter, the expanding comprising;

anchoring, in the first efferent vessel, the distal section;

anchoring, in the afferent vessel, the proximal section; and

positioning the protruding section to abut an ostium of the aneurysm on a side of the aneurysm that is adjacent to the second efferent vessel, wherein, while in the expanded configuration, a maximum cross-sectional dimension of the protruding section is greater than a maximum cross-sectional dimension of the proximal section and a maximum cross-sectional dimension of the distal section;

wherein, while in the compressed configuration, first cells of the proximal section and/or the distal section have a first compressed cell size greater than a second compressed cell size of second cells of the protruding section, and wherein, while in the expanded configuration, the first cells have a first expanded cell size that is substantially equal to a second expanded cell size of the second cells.