Detecting conditions associated with medical device operations using matched filters

• US 10,124,113 B2
• Filed: 06/24/2016
• Issued: 11/13/2018
• Est. Priority Date: 08/13/2013
• Status: Active Grant

• Current Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Inventors: Tieck, R. Marie, Alderete, Jr., Juan M., Haller, Matthew I.
• Primary Examiner(s): Stiles, Amber
• Application Number:
  US15/192,877
• Publication Number:
  US 20160303319A1
• Time in Patent Office: 872 Days
• CPC Class Codes: A61M 2005/16863 Occlusion detection
• CPC Class Codes: A61M 2205/3303 Using a biosensor
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 2205/3317 Electromagnetic, inductive or dielectric measuring means
• CPC Class Codes: A61M 2205/332 Force measuring means
• CPC Class Codes: A61M 2205/3584 using modem, internet or bluetooth
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2230/201 Glucose concentration
• CPC Class Codes: A61M 5/14216 Reciprocating piston type
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/1452 pressurised by means of pistons
• CPC Class Codes: A61M 5/16831 Monitoring, detecting, signalling or eliminating infusion flow anomalies low-level float-valves causing cut-off A61M5/40; indicating or recording presence, absence or direction of flow in general G01P13/0066

Abstract

Apparatus are provided for infusion devices and related operating methods. An exemplary device includes a sensing arrangement to provide an output indicative of a characteristic that is influenced by operation of the device, and a control module that is coupled to the sensing arrangement to apply a matched filter corresponding to a condition associated with the operation of the device to the output of the sensing arrangement and detect that condition based on the filtered output. In one example, the device includes a motor coupled to a plunger of a reservoir and operable to displace the plunger, wherein the characteristic is a force opposing displacement of the plunger and the control module detects an occlusion condition in a fluid path from the reservoir based on filtered force measurements.

Claims

1. A method of detecting a condition associated with operation of a fluid infusion device, the method comprising:

obtaining an output indicative of a characteristic influenced by the operation of a fluid infusion device from a sensing arrangement;

interpolating the output of the sensing arrangement to obtain correlated output values comprising estimated output values for intermediate values of an analysis domain variable between analysis domain variable values corresponding to the output, wherein the analysis domain variable is associated with a matched filter corresponding to the condition;

applying the matched filter to the correlated output values to calculate a filtered output as a weighted sum of the respective correlated output values using filter coefficient values of the matched filter as weighting factors for the respective correlated output values; and

detecting the condition based on the filtered output.

2. The method of claim 1, further comprising:

identifying a current physical configuration of the fluid infusion device; and

selecting the matched filter associated with the current physical configuration.

3. The method of claim 1, further comprising:

identifying a current operating mode for the fluid infusion device; and

selecting the matched filter associated with the current operating mode.

4. The method of claim 1, the fluid infusion device includes a motor operable to displace a plunger of a reservoir to deliver fluid to a user, wherein the output is influenced by displacement of the plunger.

5. The method of claim 4, wherein:

obtaining the output comprises obtaining a force measurement output indicative of a force opposing the displacement of the plunger from a force sensing arrangement;

applying the matched filter comprises applying the matched filter corresponding to an occlusion condition to the force measurement output, resulting in a filtered force measurement; and

detecting the condition comprises detecting the occlusion condition when a magnitude of the filtered force measurement is greater than an occlusion force threshold.

6. The method of claim 4, wherein:

obtaining the output comprises obtaining a volume measurement output indicative of a remaining volume of fluid in the reservoir from a volume sensing arrangement;

applying the matched filter comprises applying the matched filter corresponding to a leakage condition to the volume measurement output, resulting in a filtered volume measurement; and

detecting the condition comprises detecting the leakage condition based on the filtered volume measurement.

7. The method of claim 1, wherein detecting the condition based on the filtered output comprises detecting the condition based on the weighted sum.

8. The method of claim 1, the filter coefficient values comprising a first set of values corresponding to an expected output from the sensing arrangement in response to the condition and a second set of values to cancel the first set of values such that an integral of the matched filter is equal to zero, wherein the method further comprises scaling the first set of values and the second set of values so that the second set of values comprise integer values equal to a power of two.

9. The method of claim 1, the analysis domain variable comprising a number of motor steps and the output comprising force measurements obtained before and after an operation of a motor, wherein interpolating the output comprises interpolating the force measurements to estimate force measurement values for each incremental motor step during the operation of the motor.

10. A method of detecting an occlusion condition associated with operation of a fluid infusion device including a motor operable to displace a plunger of a reservoir to deliver fluid, the method comprising:

obtaining a force measurement output indicative of a force opposing displacement of the plunger from a force sensing arrangement;

interpolating the force measurement output to obtain correlated force measurements comprising estimated force measurement values for intermediate values of motor steps between respective motor steps corresponding to the force measurement output, resulting in correlated force measurements;

applying a matched filter corresponding to the occlusion condition to the correlated force measurements to calculate a filtered force measurement as a weighted sum of the respective correlated force measurements using filter coefficient values of the matched filter as weighting factors for the respective correlated force measurements; and

detecting the occlusion condition based on the filtered force measurement.

11. The method of claim 10, further comprising:

identifying a current physical configuration of the fluid infusion device; and

selecting the matched filter associated with the current physical configuration.

12. The method of claim 10, further comprising:

identifying a current operating mode for the fluid infusion device; and

selecting the matched filter associated with the current operating mode.

13. The method of claim 10, wherein interpolating the force measurement output comprises interpolating force measurements to estimate force measurement values for each incremental motor step during the operation of the motor.

14. The method of claim 10, wherein detecting the occlusion condition comprises detecting the occlusion condition when a magnitude of the filtered force measurement is greater than an occlusion force threshold.

15. A method of detecting a leakage condition associated with operation of a fluid infusion device including a motor operable to displace a plunger of a reservoir to deliver fluid, the method comprising:

obtaining a volume measurement output indicative of a remaining volume of fluid in the reservoir from a volume sensing arrangement;

interpolating the volume measurement output to obtain correlated volume measurements comprising estimated volume measurement values for intermediate values of motor steps between respective motor steps corresponding to the volume measurement output, resulting in correlated volume measurements;

applying a matched filter corresponding to the leakage condition to the correlated volume measurements to calculate a filtered volume measurement as a weighted sum of the respective correlated volume measurements using filter coefficient values of the matched filter as weighting factors for the respective correlated volume measurements; and

detecting the leakage condition based on the filtered volume measurement.

16. The method of claim 15, further comprising:

identifying a current physical configuration of the fluid infusion device; and

selecting the matched filter associated with the current physical configuration.

17. The method of claim 15, further comprising:

identifying a current operating mode for the fluid infusion device; and

selecting the matched filter associated with the current operating mode.

18. The method of claim 15, wherein interpolating the volume measurement output comprises interpolating volume measurements to estimate volume measurement values for each incremental motor step during the operation of the motor.