Ambulatory phrenic nerve stimulation detection

• US 10,124,174 B2
• Filed: 08/16/2016
• Issued: 11/13/2018
• Est. Priority Date: 03/13/2013
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Rockweiler, Holly, Saha, Sunipa, McCabe, Aaron R., Siejko, Krzysztof Z.
• Primary Examiner(s): Porter, Jr., Allen
• Application Number:
  US15/237,831
• Publication Number:
  US 20160354610A1
• Time in Patent Office: 819 Days
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/3702 Physiological parameters A61N1/365 takes precedence; evoked response A61N1/371

Abstract

An example of a system includes an implantable medical device (IMD) for implantation in a patient, where the IMD includes a cardiac pace generator, phrenic nerve stimulation (PS) sensor, a memory, and a controller, and where the controller is operably connected to the cardiac pace generator to generate cardiac paces. The controller is configured to provide a trigger for conducting a PS detection procedure and perform the PS detection procedure in response to the trigger. In performing the PS detection procedure the controller is configured to receive a signal from the sensor, detect PS using the signal from the sensor, and record the PS detection in storage within the IMD.

Claims

1. A system, comprising:

an implantable medical device (IMD) for implantation in a patient indicated for a prescribed myocardial therapy to provide a therapeutic benefit to the patient in an ambulatory setting, wherein the prescribed myocardial therapy has at least a first pacing configuration having a first pacing vector and a second pacing configuration having a second pacing vector, the IMD including a cardiac pace generator, a cardiac activity sensor, a memory, a controller and a phrenic nerve stimulation (PS) sensor, wherein the PS sensor is configured to provide a signal for use in detecting PS, and the controller is configured to provide the prescribed myocardial therapy by implementing a cardiac pacing algorithm to use sensed cardiac activity from the cardiac sensor to determine times for cardiac paces, and is operably connected to the cardiac pace generator to operate in different pacing configurations to generate cardiac paces at the determined times using different pacing vectors representing different combinations of source and sink electrodes, the different pacing configurations including the first pacing configuration and the second pacing configuration of the prescribed myocardial therapy,

wherein the controller is configured to avoid PS when providing the prescribed myocardial therapy by implementing a process including;

monitor the signal provided from the PS sensor when providing the prescribed myocardial therapy using the first pacing configuration that has the first pacing vector, and detect an amplitude of the monitored signal provided from the PS sensor,

compare the detected amplitude to a PS threshold to detect PS, and continue to provide the prescribed myocardial therapy using the first pacing configuration that has the first pacing vector when the detected amplitude is less than the threshold, and

automatically perform a pacing vector change to change the first pacing configuration to the second pacing configuration that has the second pacing vector to avoid PS when the detected amplitude is higher than the threshold and then continue to provide the prescribed myocardial therapy using the second pacing configuration.

2. The system of claim 1 wherein the first pacing configuration is one of a left ventricle bipolar configuration, a left ventricle to can configuration, or a left ventricle to right ventricle configuration and the second pacing configuration is different than the first pacing configuration and is one of a left ventricle bipolar configuration, a left ventricle to can configuration, or a left ventricle to right ventricle configuration.

3. The system of claim 2, wherein the left ventricle bipolar configuration, the left ventricle to can configuration, and the left ventricle to right ventricle configuration have different cathodes for delivering myocardial stimulation.

4. The system of claim 2, wherein the controller is configured to determine a PS threshold for the second pacing configuration.

5. The system of claim 2 wherein the PS sensor includes at least one sensor selected from the group of sensors consisting of:

an accelerometer, a posture sensor, an acoustic sensor, a respiration sensor, an impedance sensor, a neural sensor, a metabolic sensor, and an electromyogram sensor.

6. The system of claim 2 wherein the controller is further configured to store the result of comparison of the sensed amplitude to the PS threshold.

7. The system of claim 6 wherein the controller is configured to associate a pacing configuration with the stored result and automatically change the pacing configuration to avoid a pacing configuration where the stored result indicates an association with PS.

8. The system of claim 2 wherein the controller is further configured to modify a pacing vector to reduce PS.

9. The system of claim 2, further comprising an external PS sensor configured to sense PS in the patient.

10. The system of claim 9 wherein the external PS sensor includes an accelerometer.

11. A system, comprising:

an implantable cardiac pacemaker configured to sense cardiac activity and provide a prescribed myocardial therapy to a patient indicated for the prescribed myocardial therapy to provide a therapeutic benefit to the patient in an ambulatory setting, wherein the prescribed myocardial therapy has at least a first pacing configuration having a first pacing vector and a second pacing configuration having a second pacing vector, and the prescribed myocardial therapy is implemented using a cardiac pacing algorithm to use sensed cardiac activity to determine times for cardiac paces, wherein the implantable cardiac pacemaker is configured to deliver cardiac paces at the determined times, and to deliver cardiac paces using different pacing vectors representing different combinations of source and sink electrodes; and

a phrenic nerve stimulation (PS) sensor configured to provide a signal for use in detecting PS,

wherein the implantable cardiac pacemaker includes a controller configured to implement the cardiac pacing algorithm and avoid PS when providing the prescribed myocardial therapy by implementing a process including;

monitor the signal provided from the PS sensor when providing the prescribed myocardial therapy to using the first pacing configuration that has the first pacing vector, detect an amplitude of the monitored signal provided from the PS sensor;

compare the detected amplitude to a PS threshold to detect PS, and continue to provide the prescribed myocardial therapy using the first pacing configuration that has the first pacing vector when the detected amplitude is less than the threshold; and

automatically perform a pacing vector change to the second pacing configuration that has the second pacing vector to avoid PS when the sensed amplitude is higher than the threshold, and then continuing to implement the prescribed myocardial therapy using the second pacing configuration that has the second pacing vector.

12. The system of claim 11, wherein the PS sensor includes an implantable PS sensor.

13. The system of claim 11, wherein the PS sensor includes an external PS sensor.

14. The system of claim 11, wherein the pacing vector change includes using a different electrode as a cathode for the cardiac paces.

15. The system of claim 11, wherein the PS sensor includes an accelerometer.

16. The system of claim 11, wherein the PS sensor includes an acoustic sensor.

17. The system of claim 11, wherein the PS sensor includes a respiration sensor.

18. The system of claim 11, wherein the PS sensor includes an impedance sensor.

19. The system of claim 11, wherein the PS sensor includes a neural sensor.

20. The system of claim 11, wherein the PS sensor includes an electromyogram sensor.