System for automatically amending energy field characteristics in the application of an energy field to a living organism for treatment of invasive agents

• US 10,124,186 B2
• Filed: 12/23/2015
• Issued: 11/13/2018
• Est. Priority Date: 01/24/2011
• Status: Active Grant

• Current Assignee: Endomagnetics Ltd.
• Original Assignee: Endomagnetics Ltd.
• Inventors: McKenna, Daniel B., Frantz, Karl M.
• Primary Examiner(s): Remaly, Mark
• Application Number:
  US14/757,629
• Publication Number:
  US 20160151636A1
• Time in Patent Office: 1,056 Days
• CPC Class Codes: A61B 18/04 by heating by applying electromagnetic radiation A61B18/18; hyperthermia using electric or magnetic fields, radiation or ultrasound A61N
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/0515 Magnetic particle imaging
• CPC Class Codes: A61N 2/002 in combination with another treatment
• CPC Class Codes: A61N 2/004 specially adapted for a specific therapy
• CPC Class Codes: A61N 2/02 using magnetic fields produced by coils, including single turn loops or electromagnets A61N2/12 takes precedence

Abstract

The Energy Field and Target Correlation System automatically correlates the characteristics of target particles and a living organism to compute the characteristics of an energy field that is applied to a living organism to activate the target particles which are bound to or consumed or taken up by invasive agents in the living organism to produce detectable effects which can be used to treat the invasive agents. The energy field must be crafted to properly control the response and localize the extent of the illumination. The System automatically selects a set of energy field characteristics, including: field type, frequency, field strength, duration, field modulation, repetition frequency, beam size, and focal point. The determined energy field characteristics then are used to activate field generators to generate the desired energy field.

Claims

1. A cancer treatment system comprising:

a plurality of magnetic particles for insertion into a patient;

a magnetic field generator generating an AC magnetic field having a maximum magnetic field intensity; and

a temperature detector, in communication with the magnetic field generator, the temperature detector configured with a probe to detect the temperature of the magnetic particles located within the patient;

wherein said magnetic field generator adjusts the maximum magnetic field intensity in response to the temperature of the magnetic particles so as to maintain the magnetic particles at a predetermined temperature.

2. The cancer treatment system of claim 1 wherein the magnetic particles respond to exposure to the AC magnetic field with the production of heat.

3. The system of claim 1 wherein the temperature detector senses changes in tissue permittivity.

4. The system of claim 1 wherein the temperature detector senses changes in tissue conductivity.

5. The system of claim 1 wherein the predetermined temperature is substantially 42 degrees Celsius.

6. The system of claim 1 wherein the AC magnetic field has a frequency of 200 kHz - 1 Mhz.

7. A method operating a cancer treatment system for use in heating magnetic particles, which are inserted into patient in a manner so as to destroy cancer tissue, the method comprising the steps of:

inserting a plurality of magnetic particles into the patient;

positioning the patient for exposure to an AC magnetic field having a maximum intensity;

generating an AC magnetic field to excite the magnetic particles to a predetermined temperature;

measuring the temperature of the excited target particles within the patient; and

adjusting the maximum AC magnetic field in response to the measured temperature of the excited target particles so as to maintain the temperature of the target particles at a predetermined temperature.

8. The method of claim 7 wherein the predetermined temperature is substantially 42 degrees Celsius.

9. The method of claim 7 wherein the AC magnetic field has a frequency of 200 kHz - 1 Mhz.