Systems and methods for biological analysis and computation
First Claim
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1. A microfluidic device, comprising:
- (a) a chamber comprising (i) a first surface having a width (W) and a length (L), (ii) a second surface parallel to the first surface, and (iii) a space between the first surface and the second surface having a height (H), wherein the space between the first surface and second surface is configured to direct fluid flow and H is less than about 3 millimeters (mm); and
(b) an input funnel having (i) a wide end spanning the width of the first surface and in fluid communication with the space between the first surface and the second surface, and (ii) a narrow end medial to the wide end and in fluid communication with the wide end, wherein the wide end has a first thickness (t0) at its mid-point, a second thickness (t1) at its edges, and a height (h) between the wide end to the narrow end,wherein (t0) is less than (t1).
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Abstract
Provided herein are devices and methods suitable for sequencing, detecting, amplifying, analyzing, and performing sample preparation procedures for nucleic acids and other molecules. In some cases, the devices and methods provided herein are used for computation.
232 Citations
17 Claims
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1. A microfluidic device, comprising:
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(a) a chamber comprising (i) a first surface having a width (W) and a length (L), (ii) a second surface parallel to the first surface, and (iii) a space between the first surface and the second surface having a height (H), wherein the space between the first surface and second surface is configured to direct fluid flow and H is less than about 3 millimeters (mm); and (b) an input funnel having (i) a wide end spanning the width of the first surface and in fluid communication with the space between the first surface and the second surface, and (ii) a narrow end medial to the wide end and in fluid communication with the wide end, wherein the wide end has a first thickness (t0) at its mid-point, a second thickness (t1) at its edges, and a height (h) between the wide end to the narrow end, wherein (t0) is less than (t1). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification