Heart sound monitoring of pulmonary hypertension

• US 10,130,267 B2
• Filed: 03/06/2013
• Issued: 11/20/2018
• Est. Priority Date: 03/08/2012
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Song, Zhendong, Zhou, Xiaohong
• Primary Examiner(s): Cheng, Jacqueline
• Assistant Examiner(s): PORTILLO, JAIRO H
• Application Number:
  US13/786,778
• Publication Number:
  US 20130237863A1
• Time in Patent Office: 2,085 Days
• Field of Search: 607 4
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/352 Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
• CPC Class Codes: A61B 5/7285 for synchronising or triggering a physiological measurement or image acquisition with a physiological event or waveform, e.g. an ECG signal A61B6/5205, A61B6/541, A61B8/5207, A61B8/543 take precedence
• CPC Class Codes: A61B 7/00 Instruments for auscultation
• CPC Class Codes: A61B 7/003 Detecting lung or respiration noise
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

A medical device system and method that includes sensing a heart sound signal from a first external sensor, determining whether a pulmonary hypertension signature is detected in response to the sensed heart sound signal, sensing a lung sound signal from a second external sensor, determining whether a heart failure signature is detected in response to the sensed lung sound signal, and determining therapy parameters in response to determining whether a pulmonary hypertension signature is detected and determining whether a heart failure signature is detected.

Claims

1. A method comprising:

analyzing a heart sound signal of a patient for a time interval from a first external sensor to detect a pulmonary hypertension signature;

analyzing a lung sound signal of the patient for the time interval from a second external sensor to detect a heart failure-signature;

when one of the heart failure signature or the pulmonary hypertension signature is detected, then determine whether the other of the heart failure signature or the pulmonary hypertension signature is detected;

delivering a first therapy to the patient via a medical device in response to detecting the pulmonary hypertension signature but not the heart failure signature, the first therapy having a first set of therapy parameters;

delivering a second therapy to the patient via the medical device in response to detecting the heart failure signature but not the pulmonary hypertension signature, the second therapy having a second set of therapy parameters; and

delivering a third therapy to the patient via the medical device in response to detecting both the pulmonary hypertension signature based on the analyzed heart sound signal and the heart failure signature based on the analyzed lung sound signal, the third therapy having a third set of therapy parameters.

2. The method of claim 1, further comprising detecting pulmonary hypertension induced heart failure progression in response to detecting both the pulmonary hypertension signature and the heart failure signature.

3. The method of claim 1, further comprising:

determining an A2 heart sound signal and a P2 heart sound signal in response to the analyzed heart sound signal;

determining at least one P2 heart sound signal parameter from the P2 heart sound signal; and

determining pulmonary arterial pressure in response to the at least one P2 heart sound signal parameter.

4. The method of claim 3, further comprising:

comparing at least one A2 heart sound signal parameter and the at least one P2 heart sound signal parameter; and

determining an indication of pulmonary hypertension in response to the comparing.

5. The method of claim 3, further comprising:

receiving an arterial blood pressure signal from an external blood pressure monitor; and

associating at least one A2 heart sound signal parameter with the arterial blood pressure signal.

6. The method of claim 3, further comprising:

receiving a pulmonary pressure signal from a pressure catheter; and

calibrating the at least one P2 heart sound signal parameter with the pulmonary pressure signal.

7. The method of claim 3, further comprising:

determining whether an amplitude of the P2 heart sound signal is greater than a predetermined threshold;

comparing the P2 heart sound signal and a predetermined heart failure signature; and

determining pulmonary hypertension induced heart failure progression in response to the comparing.

8. The method of claim 7, further comprising analyzing a split between A2 heart sound and a P2 heart sound in an S2 heart sound.

9. The method of claim 1, wherein the first set of therapy parameters are different than the second set of therapy parameters and the third set of therapy parameters, and the second set of therapy parameters are different that the third set of therapy parameters.

10. The method of claim 1, wherein each of the first therapy, the second therapy, and the third therapy comprises at least one of electrical stimulation therapy or drug delivery therapy.

11. A medical device system comprising:

a first external sensor configured to sense a heart sound of a patient;

a second external sensor configured to sense a lung sound signal of the patient;

a medical device including a therapy delivery module configured to delivery therapy to a patient; and

a processor configured to analyze a heart sound signal for a time interval from the first external sensor to detect a pulmonary hypertension signature, analyze a lung sound signal for the time interval from the second external sensor to detect a heart failure signature, when one of the heart failure signature or the pulmonary hypertension signature is detected, then determine whether the other of the heart failure signature or the pulmonary hypertension signature is detected, control delivery of a first therapy to the patient via the medical device in response to detecting the pulmonary hypertension signature but not the heart failure signature, the first therapy having a first set of therapy parameters, control delivery of a second therapy to the patient via the medical device in response to detecting the heart failure signature but not the pulmonary hypertension signature, the second therapy having a second set of therapy parameters; and

control delivery of a third therapy to the patient via the medical device in response to detecting both the pulmonary hypertension signature based on the analyzed heart sound signal and the heart failure signature based on the analyzed lung sound signal, the third therapy having a third set of therapy parameters.

12. The medical device system of claim 11, wherein the processor is further configured to detect pulmonary hypertension induced heart failure progression in response to detecting both the pulmonary hypertension signature and heart failure signature.

13. The medical device system of claim 11, wherein the processor is further configured to determine an A2 heart sound signal and a P2 heart sound signal in response to the analyzed heart sound signal, determine at least one P2 heart sound signal parameter from the P2 heart sound signal, and determine pulmonary arterial pressure in response to the at least one P2 heart sound signal parameter.

14. The medical device system of claim 13, wherein the processor is further configured to compare at least one A2 heart sound signal parameter and the at least one P2 heart sound signal parameter, and determine an indication of pulmonary hypertension in response to the comparing.

15. The medical device system of claim 13, further comprising:

an external blood pressure monitor; and

a telemetry module configured to receive an arterial blood pressure signal from the external blood pressure monitor, wherein the processor is further configured to associate at least one A2 heart sound signal parameter with the arterial blood pressure signal.

16. The medical device system of claim 13, further comprising:

a pressure catheter sensing a pulmonary pressure signal; and

a telemetry module configured to receive a pulmonary pressure signal from the pressure catheter, wherein the processor is further configured to calibrate the at least one P2 heart sound signal parameter with the pulmonary pressure signal.

17. The medical device system of claim 13, wherein the processor is further configured to determine whether an amplitude of the P2 heart sound signal is greater than a predetermined threshold, compare the P2 heart sound signal and a predetermined heart failure signature, and determine pulmonary hypertension induced heart failure progression in response to the comparing.

18. The medical device system of claim 17, wherein the processor is further configured to analyze a split between A2 heart sound and a P2 heart sound in an S2 heart sound.

19. The medical device system of claim 11, wherein the first set of therapy parameters are different than the second set of therapy parameters and the third set of therapy parameters, and the second set of therapy parameters are different that the third set of therapy parameters.

20. The medical device system of claim 11, wherein each of the first therapy, the second therapy, and the third therapy comprises at least one of electrical stimulation therapy or drug delivery therapy.

21. A non-transitory computer-readable medium comprising instructions for causing a programmable processor to:

analyze a heart sound signal of a patient for a time interval from a first external sensor to detect a pulmonary hypertension signature;

analyze a lung sound signal of the patient for the time interval from a second external sensor to detect a heart failure signature;

when one of the heart failure signature or the pulmonary hypertension signature is detected, then determine whether the other of the heart failure signature or the pulmonary hypertension signature is detected;

control delivery of a first therapy to the patient via a medical device in response to detecting the pulmonary hypertension Signature but not the heart failure signature, the first therapy having a first set of therapy parameters;

control delivery of a second therapy to the patient via the medical device in response to detecting the heart failure signature but not the pulmonary hypertension signature, the second therapy having a second set of therapy parameters; and

control delivery of a third therapy to the patient via the medical device in response to detecting both the pulmonary hypertension signature based on the analyzed heart sound signal and the heart failure signature based on the analyzed lung sound signal, the third therapy having a third set of therapy parameters.

22. A medical device system comprising:

a first external sensor configured to sense a heart sound of a patient;

a second external sensor configured to sense a lung sound signal of the patient;

a medical device including a therapy delivery module configured to delivery therapy to a patient;

a processor configured to analyze a heart sound signal for a time interval from the first external sensor to detect a pulmonary hypertension signature, analyze a lung sound signal for the time interval from the second external sensor to detect a heart failure signature, when one of the heart failure signature or the pulmonary hypertension signature is detected, then determine whether the other of the heart failure signature or the pulmonary hypertension signature is detected, control delivery of a first therapy to the patient via the medical device in response to detecting the pulmonary hypertension signature but not detecting the heart failure signature, the first therapy having a first set of therapy parameters;

control delivery of a second therapy to the patient via the medical device in response to detecting the heart failure signature but not the pulmonary hypertension signature, the second therapy having a second set of therapy parameters; and

control delivery of a third therapy to the patient via the medical device in response to detecting both the pulmonary hypertension signature based on the analyzed heart sound signal and the heart failure signature based on the analyzed lung sound signal;

, the third therapy having a third set of therapy parameters; and

an external programmer device including a graphical user interface configured to display an indicator of at least one of the analyzed lung sound, the analyzed heart sound, the detection of the pulmonary hypertension signature but not the heart failure signal, the detection of the heart failure signature but not the pulmonary hypertension signature, or the detection of both the pulmonary hypertension signature and the heart failure signature.

23. A method comprising:

analyzing a heart sound signal of a patient from a first external sensor to detect a pulmonary hypertension signature and separately analyzing a lung sound signal of the patient from a second external sensor to detect a heart failure signature;

determining that one of the heart failure signature or the pulmonary hypertension signature is detected;

determining, in response to the determination that the one of the heart failure signature or the pulmonary hypertension signature is detected, whether the other of the heart failure signature or the pulmonary hypertension signature is detected;

delivering a first therapy to the patient via a medical device in response to detecting the pulmonary hypertension signature but not the heart failure signature, the first therapy having a first set of therapy parameters;

delivering a second therapy to the patient via the medical device in response to detecting the heart failure signature but not the pulmonary hypertension signature, the second therapy having a second set of therapy parameters; and

delivering a third therapy to the patient via the medical device in response to detecting both the pulmonary hypertension signature based on the analyzed heart sound signal and the heart failure signature based on the analyzed lung sound signal, the third therapy having a third set of therapy parameters.