Coated sensors, and corresponding systems and methods
First Claim
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1. An analyte sensor having a sensing element and a support element, at least one of the sensing element and support element having a crosslinked basement membrane preparation formed thereon, wherein the crosslinked basement membrane preparation is substantially free from glucose, amino acids, salts and vitamins having a molecular weight of 2000 daltons or less.
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Abstract
Disclosed herein are sensors with a layer of dehydrated modified basement membrane preparation formed thereon. The basement membrane has been modified before dehydration of remove low molecular weight components. In some embodiments, the basement membrane is crosslinked. Methods of making and using the products also are disclosed.
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Citations
21 Claims
- 1. An analyte sensor having a sensing element and a support element, at least one of the sensing element and support element having a crosslinked basement membrane preparation formed thereon, wherein the crosslinked basement membrane preparation is substantially free from glucose, amino acids, salts and vitamins having a molecular weight of 2000 daltons or less.
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7. A method comprising:
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obtaining a basement membrane preparation containing basement membrane and at least one member selected from the group consisting of salts, glucose, individual amino acids, and vitamins, removing at least a portion of at least one of the salts, glucose, individual amino acids and vitamins from the basement membrane to form a modified basement membrane preparation, obtaining a sensor, placing the modified basement membrane preparation in the form of a liquid or gel on the sensor, and crosslinking and dehydrating the modified basement membrane preparation on the sensor. - View Dependent Claims (8, 9, 10, 19, 20, 21)
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- 11. An analyte sensor having a sensing element and a support element, at least one of the sensing element and support element having a basement membrane preparation formed thereon that is crosslinked with a di-aldehyde, wherein the crosslinked basement membrane preparation is substantially free from glucose, amino acids, salts and vitamins having a molecular weight of 2000 daltons or less.
Specification