Pharmaceutical formulation containing gelling agent
First Claim
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1. A controlled release oral solid dosage form comprising:
- (i) a first population of particles comprising an opioid analgesic, and(ii) a second population of particles comprising a gelling agent,wherein the particles of the first population are free from the gelling agent,the particles of the second population are free from the opioid analgesic, andwhen exposed to from about 0.5 ml to about 10 ml of water, the dosage form forms a gel that cannot be drawn into an insulin syringe without picking up pockets of air.
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Abstract
Disclosed in certain embodiments is a controlled release oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse together with one or more pharmaceutically acceptable excipients; the dosage form further including a gelling agent in an effective amount to impart a viscosity unsuitable for administration selected from the group consisting of parenteral and nasal administration to a solubilized mixture formed when the dosage form is crushed and mixed with from about 0.5 to about 10 ml of an aqueous liquid; the dosage form providing a therapeutic effect for at least about 12 hours when orally administered to a human patient.
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Citations
20 Claims
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1. A controlled release oral solid dosage form comprising:
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(i) a first population of particles comprising an opioid analgesic, and (ii) a second population of particles comprising a gelling agent, wherein the particles of the first population are free from the gelling agent, the particles of the second population are free from the opioid analgesic, and when exposed to from about 0.5 ml to about 10 ml of water, the dosage form forms a gel that cannot be drawn into an insulin syringe without picking up pockets of air. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A controlled release oral solid dosage form comprising:
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(i) a first population of particles comprising an opioid analgesic, and (ii) a second population of particles comprising a gelling agent, wherein the particles of the first population are free from the gelling agent, the particles of the second population are free from the opioid analgesic, and when exposed to from about 0.5 ml to about 10 ml of water, the dosage form forms a gel that cannot be injected from an insulin syringe. - View Dependent Claims (17, 18, 19, 20)
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Specification