Filtration system for preparation of fluids for medical applications

• US 10,130,746 B2
• Filed: 06/28/2016
• Issued: 11/20/2018
• Est. Priority Date: 01/07/2003
• Status: Expired due to Term

• Current Assignee: Nxstage Medical Incorporated (Fresenius SE & Co. KGaA)
• Original Assignee: Nxstage Medical Incorporated (Fresenius SE & Co. KGaA)
• Inventors: Burbank, Jeffrey H., Treu, Dennis M., McDowell, Christopher S., Friederichs, Goetz
• Primary Examiner(s): Menon, Krishnan S
• Application Number:
  US15/195,801
• Publication Number:
  US 20160303305A1
• Time in Patent Office: 875 Days
• Field of Search: None
• CPC Class Codes: A61M 1/1656 Apparatus for preparing dialysates
• CPC Class Codes: A61M 1/1668 Details of containers
• CPC Class Codes: A61M 1/1672 using membrane filters, e.g. for sterilising the dialysate
• CPC Class Codes: A61M 1/1674 using UV radiation sources for sterilising the dialysate
• CPC Class Codes: A61M 2205/33 Controlling, regulating or measuring
• CPC Class Codes: A61M 2205/75 with filters
• CPC Class Codes: A61M 3/00 Medical syringes, e.g. enemata; Irrigators A61M5/00 takes precedence; pistons A61M5/315
• CPC Class Codes: B01D 2311/04 Specific process operations in the feed stream; Feed pretreatment
• CPC Class Codes: B01D 2311/243 Electrical conductivity control
• CPC Class Codes: B01D 2311/26 Further operations combined with membrane separation processes
• CPC Class Codes: B01D 2311/2619 UV-irradiation
• CPC Class Codes: B01D 2311/2623 Ion-Exchange
• CPC Class Codes: B01D 2311/2626 Absorption or adsorption
• CPC Class Codes: B01D 2313/04 Specific sealing means
• CPC Class Codes: B01D 2313/14 Specific spacers
• CPC Class Codes: B01D 2313/16 Specific vents
• CPC Class Codes: B01D 2317/02 Elements in series
• CPC Class Codes: B01D 2319/02 Elements in series
• CPC Class Codes: B01D 61/06 Energy recovery
• CPC Class Codes: B01D 61/145 Ultrafiltration
• CPC Class Codes: B01D 61/146 : comprising multiple ultrafiltration steps
• CPC Class Codes: B01D 61/22 : Controlling or regulating
• CPC Class Codes: B01D 61/243 : Dialysis
• CPC Class Codes: B01D 61/28 : Apparatus therefor
• CPC Class Codes: B01D 61/32 : Controlling or regulating
• CPC Class Codes: B01D 61/44 : Ion-selective electrodialysis
• CPC Class Codes: C02F 1/283 : using coal, charred products, or inorganic mixtures containing them
• CPC Class Codes: C02F 1/32 : with ultraviolet light
• CPC Class Codes: C02F 1/42 : by ion-exchange ion-exchange in general B01J
• CPC Class Codes: C02F 1/444 : by ultrafiltration or microfiltration
• CPC Class Codes: C02F 2001/422 : using anionic exchangers
• CPC Class Codes: C02F 2001/425 : using cation exchangers
• CPC Class Codes: C02F 2103/026 : Treating water for medical or cosmetic purposes
• CPC Class Codes: C02F 2209/008 : comprising telecommunication features, e.g. modems or antennas
• CPC Class Codes: C02F 2209/05 : Conductivity or salinity

Abstract

Systems, methods, and devices for preparation of water for various uses including blood treatment are described. In embodiments, fluid is passed through a first filtration step which is effective for creating purified water and a pair of ultrafilters placed at the outlet. The ultrafilters are separated by an intervening flow path to prevent grow-through from the outlet end upstream. In embodiments, a recirculation path with an air removing filter helps to eliminate air from the ultimate product water.

Claims

1. A method of performing a medical treatment, comprising:

at a time prior to a dialysis treatment, pumping water into a water purification device, including a disposable filter module that includes deionization filters, to generate product water having a resistivity of at least 2 megohms;

passing the product water from said pumping through a resistivity monitor configured to shut down said pumping when a measured resistivity falls below said 2 megohms;

fluidly coupling a disposable batch container to receive the product water;

combining said product water with a concentrate from a concentrate container for holding the concentrate to produce a mixture in the disposable batch container that is empty before the fluidly coupling and is preattached to the concentrate container, the concentrate container and the batch container being sterilized together as one consumable unit;

measuring a conductivity of said mixture in said batch container using a conductivity sensor permanently attached to said batch container; and

pumping said mixture from said batch container to administer the dialysis treatment.

2. The method of claim 1, wherein the concentrate container and the batch container are interconnected by tubing containing a sterile filter.

3. The method of claim 1, further comprising sterile-filtering said product water prior to said combining.

4. The method of claim 1, wherein the measuring includes drawing a sample of said mixture over the conductivity sensor.

5. The method of claim 4, wherein the conductivity sensor is attached to a fluid port of said batch container.

6. The method of claim 1, wherein the concentrate container includes a burstable sealed membrane.

7. The method of claim 1, wherein the concentrate container is connected by tubing to said batch container.

8. The method of claim 2, further comprising sterile-filtering said product water prior to said combining.

9. The method of claim 2, wherein the measuring includes drawing a sample of said mixture over the conductivity sensor.

10. The method of claim 2, wherein the concentrate container includes a burstable sealed membrane.

11. The method of claim 2, wherein the concentrate container is connected by tubing to said batch container.

12. The method according to claim 1, wherein

said concentrate is a concentrated dialysate liquid,

said concentrate container is filled with the concentrated dialysate liquid, and

said mixture is a dialysate mixture.

13. The method according to claim 2, wherein

said concentrate is a concentrated dialysate liquid,

said concentrate container is filled with the concentrated dialysate liquid, and

said mixture is a dialysate mixture.

14. The method according to claim 8, wherein

said concentrate is a concentrated dialysate liquid,

said concentrate container is filled with the concentrated dialysate liquid, and

said mixture is a dialysate mixture.

15. The method according to claim 11, wherein

said concentrate is a concentrated dialysate liquid,

said concentrate container is filled with the concentrated dialysate liquid, and

said mixture is a dialysate mixture.

16. The method according to claim 1, wherein

the conductivity sensor protrudes into the batch container through a wall of the batch container.

17. The method according to claim 11, wherein

the conductivity sensor protrudes into the batch container through a wall of the batch container.