Intelligent pharmaceutical delivery system with automatic shutoff and method of using
First Claim
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1. A system for controlling anesthesia or sedation of a subject, the system comprising:
- a physiological signal sensor adapted to acquire a physiological signal from a subject indicative of the subject'"'"'s electroencephalogram (EEG) signal;
an infusion pump adapted to administer anesthetic or sedative to the subject; and
a controller adapted to control the infusion pump and administration of the anesthetic or sedative;
the controller comprising a processor adapted for receiving the physiological signal from the physiological signal sensor and further comprising an algorithm adapted to perform real-time quantitative monitoring of the physiological signal and from this monitoring to detect burst suppression of the subject'"'"'s EEG signal from the physiological signal,wherein the controller is further adapted to stop anesthetic or sedative administration via the infusion pump based upon a level of burst suppression of the subject'"'"'s EEG signal.
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Abstract
A system and method provides closed-loop sedation, anesthesia, or analgesia by monitoring EEG and automatically adjusting the delivery of sedative, anesthetic, and/or analgesic drugs to maintain that desired or predetermined level of cortical at all echelons of care. The system and method further monitor the subject'"'"'s cortical activity to detect occurrence of burst suppression which can be indicative of unsafe depth of anesthesia or sedation. Further, the system and methods provide for alteration or cessation of the administration of anesthesia or sedation based on the occurrence of burst suppression to mitigate harm to the subject.
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Citations
20 Claims
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1. A system for controlling anesthesia or sedation of a subject, the system comprising:
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a physiological signal sensor adapted to acquire a physiological signal from a subject indicative of the subject'"'"'s electroencephalogram (EEG) signal; an infusion pump adapted to administer anesthetic or sedative to the subject; and a controller adapted to control the infusion pump and administration of the anesthetic or sedative;
the controller comprising a processor adapted for receiving the physiological signal from the physiological signal sensor and further comprising an algorithm adapted to perform real-time quantitative monitoring of the physiological signal and from this monitoring to detect burst suppression of the subject'"'"'s EEG signal from the physiological signal,wherein the controller is further adapted to stop anesthetic or sedative administration via the infusion pump based upon a level of burst suppression of the subject'"'"'s EEG signal. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A system for controlling anesthesia or sedation of a subject, the system comprising:
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a physiological signal sensor adapted to acquire a physiological signal from a subject indicative of the subject'"'"'s electroencephalogram (EEG) signal; an infusion pump adapted to administer anesthetic or sedative to the subject; and a controller adapted to control the infusion pump and administration of the anesthetic or sedative;
the controller comprising a processor adapted for receiving the physiological signal from the physiological signal sensor and further comprising an algorithm adapted to perform real-time quantitative monitoring of the physiological signal and from this monitoring to detect burst suppression of the subject'"'"'s EEG signal from the physiological signal,wherein the controller calculates a numerical index representative of a level of cortical activity or depth of anesthesia or sedation of the subject, and the controller is adapted to control the administration of anesthetic or sedative in order to maintain the numerical index at a desired or predetermined level corresponding to a desired or predetermined level of consciousness, and further to reduce or stop anesthetic or sedative administration below that being used to maintain the desired or predetermined numerical index level via the infusion pump based upon a level of burst suppression of the subject'"'"'s EEG signal. - View Dependent Claims (9, 10, 11, 12, 13, 14)
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15. A system for controlling sedation of a subject, the system comprising:
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a physiological signal sensor adapted to acquire a physiological signal from a subject indicative of the subject'"'"'s electroencephalogram (EEG) signal; an infusion pump adapted to administer anesthetic or sedative to the subject; and a controller adapted to control the infusion pump and administration of the anesthetic or sedative;
the controller comprising a processor adapted for receiving the physiological signal from the physiological signal sensor and further comprising an algorithm adapted to perform real-time quantitative monitoring of the physiological signal and from this monitoring to detect burst suppression of the subject'"'"'s EEG signal from the physiological signal,wherein the controller is further adapted to reduce or stop the anesthetic or sedative administration via the infusion pump based upon a level of burst suppression of the subject'"'"'s EEG signal. - View Dependent Claims (16, 17, 18, 19, 20)
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Specification