Method of producing substances with supersaturated gas, transdermal delivery device thereof, and uses thereof
First Claim
Patent Images
1. A transdermal delivery device comprising:
- a) a housing includingi) an external body shell comprising a fluid chamber assembly access cover movably engaged with the external body shell;
ii) an interior compartment including an open-ended delivery outlet and a vapor producing assembly compartment; and
iii) a cartridge retaining container comprising an external covering shell and an internal cartridge compartment configured to hold a compressed therapeutic carbon dioxide gas cartridge, wherein the cartridge retaining container is detachably engaged with the external body shell;
wherein the vapor producing assembly compartment is located between the open-ended delivery outlet and the cartridge retaining container; and
b) a vapor producing assembly includingi) a fluid chamber assembly comprising a fluid container and a removable fluid container cap;
ii) a permeation valve configured to reduce the pressure of a gas removed from the compressed gas cartridge and delivered to the fluid chamber assembly to a pressure of less than 25 psi; and
iii) a delivery outlet configured to release a vapor from the fluid chamber assembly, the vapor comprising liquid particles and a supersaturated amount of dissolved gas;
wherein the vapor producing assembly is substantially contained within the vapor producing assembly compartment.
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Abstract
The present specification disclosed a noninvasive transdermal delivery device that relates generally to a handheld mechanical apparatus for noninvasive transdermal administration of gas, small to large water-soluble (hydrophilic) pharmaceutical agents, vitamins, and other therapeutic agents. Components of such delivery devices, methods of producing a substance comprising a supersaturated amount of a dissolved gas, as well as, methods of administering a therapeutic agent using such delivery devices and methods of treating a disease or condition using such delivery devices are also disclosed.
45 Citations
16 Claims
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1. A transdermal delivery device comprising:
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a) a housing including i) an external body shell comprising a fluid chamber assembly access cover movably engaged with the external body shell; ii) an interior compartment including an open-ended delivery outlet and a vapor producing assembly compartment; and iii) a cartridge retaining container comprising an external covering shell and an internal cartridge compartment configured to hold a compressed therapeutic carbon dioxide gas cartridge, wherein the cartridge retaining container is detachably engaged with the external body shell; wherein the vapor producing assembly compartment is located between the open-ended delivery outlet and the cartridge retaining container; and b) a vapor producing assembly including i) a fluid chamber assembly comprising a fluid container and a removable fluid container cap; ii) a permeation valve configured to reduce the pressure of a gas removed from the compressed gas cartridge and delivered to the fluid chamber assembly to a pressure of less than 25 psi; and iii) a delivery outlet configured to release a vapor from the fluid chamber assembly, the vapor comprising liquid particles and a supersaturated amount of dissolved gas; wherein the vapor producing assembly is substantially contained within the vapor producing assembly compartment. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A transdermal delivery device comprising:
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a) a housing including i) an external body shell comprising a fluid chamber assembly access cover movably engaged with the external body shell; ii) an interior compartment including an open-ended delivery outlet and a vapor producing assembly compartment; and iii) a cartridge retaining container comprising an external covering shell and an internal cartridge compartment configured to hold a compressed therapeutic carbon dioxide gas cartridge, wherein the cartridge retaining container is detachably engaged with the external body shell; wherein the vapor producing assembly compartment is located in between the open-ended delivery outlet and the cartridge retaining container; and b) a vapor producing assembly including i) a fluid chamber assembly comprising a fluid container and a removable fluid container cap; ii) a permeation valve configured to reduce the pressure of the therapeutic carbon dioxide gas removed from the compressed gas cartridge and delivered to the fluid chamber assembly to a pressure below about 25 psi; and iii) a delivery outlet configured to release a vapor from the fluid chamber assembly, the vapor comprising liquid particles and a supersaturated amount of dissolved gas; wherein the vapor producing assembly is substantially contained within the vapor producing assembly compartment, and the permeation valve comprises a permeable member selected from cork, textile, porous polymer or combinations thereof. - View Dependent Claims (16)
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Specification