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Irradiation of red blood cells and anaerobic storage

  • US 10,136,635 B2
  • Filed: 11/04/2011
  • Issued: 11/27/2018
  • Est. Priority Date: 05/05/2010
  • Status: Active Grant
First Claim
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1. A blood storage system for reducing irradiation damage to red blood cells comprising:

  • a collection vessel for red blood cells;

    an oxygen or oxygen and carbon dioxide depletion device comprising a cartridge;

    a plurality of hollow fibers or gas-permeable films extending within the cartridge from an entrance to an exit thereof, wherein the hollow fibers or gas-permeable films are adapted to receiving and conveying red blood cells; and

    an oxygen and carbon dioxide scavenger packed within the cartridge and contiguous to and in between the plurality of hollow fibers or gas-permeable films;

    a storage vessel for storing oxygen or oxygen and carbon dioxide-depleted red blood cells under an anaerobic condition;

    a first tubing connecting the collection vessel to the oxygen or oxygen and carbon dioxide depletion device; and

    a second tubing connecting the oxygen or oxygen and carbon dioxide depletion device to the storage vessel;

    wherein said oxygen or oxygen and carbon dioxide-depleted red blood cells are capable of being irradiated with a gamma- or X-ray irradiating device, when stored in said storage vessel; and

    wherein said irradiation damage to said oxygen and carbon dioxide-depleted red blood cells is reduced without the addition of L-carnitine or an alkanoul derivative to said blood storage system and said oxygen and carbon dioxide-depleted red blood cells.

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