Use of remote ischemic conditioning to improve outcome after myocardial infarction

• US 10,136,895 B2
• Filed: 06/19/2015
• Issued: 11/27/2018
• Est. Priority Date: 03/31/2010
• Status: Active Grant

• Current Assignee: Hospital For SICK Children
• Original Assignee: Hospital For SICK Children
• Inventors: Redington, Andrew
• Primary Examiner(s): Matthews, Howie
• Application Number:
  US14/744,665
• Publication Number:
  US 20160038147A1
• Time in Patent Office: 1,257 Days
• CPC Class Codes: A61B 17/12009 Implements for ligaturing other than by clamps or clips, e.g. using a loop with a slip knot
• CPC Class Codes: A61B 17/1327 Tensioning clamps
• CPC Class Codes: A61B 17/1355 Automated control means therefor
• CPC Class Codes: A61B 2017/00199 with a console, e.g. a control panel with a display
• CPC Class Codes: A61B 2017/00544 pneumatically
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/165 having aromatic rings, e.g. colchicine, atenolol, progabide
• CPC Class Codes: A61K 31/401 Proline; Derivatives thereof, e.g. captopril
• CPC Class Codes: A61K 31/4178 not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
• CPC Class Codes: A61K 31/4184 condensed with carbocyclic rings, e.g. benzimidazoles
• CPC Class Codes: A61P 9/04 Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

The invention provides methods for reducing the incidence and/or severity and/or delaying the onset of heart dysfunction/failure and improving overall survival through the use of remote ischemic per-conditioning and post-conditioning.

Claims

1. A method for reducing the incidence, delaying the onset, and/or reducing the severity of heart dysfunction and/or failure following a myocardial infarction comprising:

performing repeated remote ischemic conditioning (RIC) regimens on a subject beginning after an ischemic phase and a reperfusion phase of the myocardial infarction and continuing for at least three days.

2. The method of claim 1, wherein the repeated RIC regimens are commenced within 1 week after the myocardial infarction occurs.

3. The method of claim 1, wherein the repeated RIC regimens are performed every two days.

4. The method of claim 1, wherein the repeated RIC regimens are performed daily.

5. The method of claim 1, wherein the repeated RIC regimens are commenced within a month after the myocardial infarction occurs.

6. The method of claim 1, wherein the repeated RIC regimens are performed more than once per day on one or more days.

7. The method of claim 1, wherein the subject has not undergone balloon angioplasty or a stent placement.

8. The method of claim 1, wherein each RIC regimen comprises at least four cycles, each cycle comprising blood flow occlusion and reperfusion.

9. The method of claim 1, wherein each RIC regimen comprises more than one cycle, and each cycle comprises about 5 minutes of occlusion and 5 minutes of reperfusion.

10. The method of claim 9, wherein occlusion is created by a pressure that is at least 15 mmHg above systolic pressure.

11. The method of claim 1, wherein each RIC regimen is performed at the same site.

12. The method of claim 11, wherein each RIC regimen is performed on an upper limb of the subject.

13. The method of claim 1, further comprising administering to the subject an angiotensin-converting enzyme (ACE) inhibitor.

14. The method of claim 1, further comprising administering to the subject an angiotensin II receptor blocker.

15. The method of claim 1, further comprising administering to the subject an anti-platelet therapy.

16. The method of claim 1, wherein 2, 3, 4, 5 or more RIC regimens are performed on a subject in a single day.

17. The method of claim 1, wherein the repeated RIC regimens are performed for at least 28 days after the myocardial infarction.

18. The method of claim 17, wherein the repeated RIC regimens are performed for a period of one month, two months, three months, four months, five months, six months, seven months, eight months, nine months, ten months, or twelve months after the myocardial infarction occurs.

19. The method of claim 18, wherein the repeated RIC regimens are performed for a remaining lifespan of the subject.

20. The method of claim 1, wherein the repeated RIC regimens are commenced at least 12 hours after the myocardial infarction occurs.

21. The method of claim 1, wherein the repeated RIC regimens are commenced at least 6 hours after the myocardial infarction occurs.

22. The method of claim 1, wherein the repeated RIC regimens are commenced at least 24 hours after the myocardial infarction.

23. The method of claim 1, wherein the repeated RIC regimens are commenced at least 36 hours after the myocardial infarction occurs.

24. The method of claim 1, wherein adverse remodeling of a left ventricle of a heart of the subject is restricted.

25. A method for restricting adverse remodeling of a left ventricle of a heart of a subject following a myocardial infarction comprising performing repeated remote ischemic conditioning (RIC) regimens on the subject beginning after an ischemic phase and a reperfusion phase of the myocardial infarction and continuing at least daily for one or more days, the repeated RIC regimens being commenced within thirty days after the myocardial infarction occurs.