Oxygen-enabled composition

• US 10,137,146 B2
• Filed: 05/18/2018
• Issued: 11/27/2018
• Est. Priority Date: 03/30/2016
• Status: Active Grant

• Current Assignee: Baylor University
• Original Assignee: Baylor University
• Inventors: Woodmansee, Jr., John W, Woodmansee, Robert A, Bruce, Erica D
• Primary Examiner(s): Shomer, Isaac
• Application Number:
  US15/983,602
• Publication Number:
  US 20180271899A1
• Time in Patent Office: 193 Days
• Field of Search: None
• CPC Class Codes: A61K 33/08 Oxides; Hydroxides
• CPC Class Codes: A61K 47/02 Inorganic compounds
• CPC Class Codes: A61K 47/6949 inclusion complexes, e.g. clathrates, cavitates or fullerenes
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/0026 Blood substitute; Oxygen transporting formulations; Plasma extender
• CPC Class Codes: A61K 9/1611 Inorganic compounds
• CPC Class Codes: A61K 9/1682 Processes
• CPC Class Codes: A61K 9/5115 Inorganic compounds
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• CPC Class Codes: C01F 7/02 Aluminium oxide; Aluminium hydroxide; Aluminates
• CPC Class Codes: C01F 7/023 Grinding, deagglomeration or disintegration
• CPC Class Codes: C01P 2004/03 obtained by SEM
• CPC Class Codes: C01P 2004/61 Micrometer sized, i.e. from 1-100 micrometer
• CPC Class Codes: C01P 2004/62 Submicrometer sized, i.e. from 0.1-1 micrometer
• CPC Class Codes: C01P 2006/80 Compositional purity
• CPC Class Codes: Y10S 977/773 Nanoparticle, i.e. structure having three dimensions of 100 nm or less

Abstract

A composition of chlorine-free poly-oxygenated metal hydroxide that comprises a clathrate containing oxygen gas molecules, and which may comprise a nutraceutical. In one embodiment, the poly-oxygenated metal hydroxide composition is soluble, and may have particles having a diameter of 212 μm or less. The poly-oxygenated metal hydroxide may comprise of a poly-oxygenated aluminum hydroxide. The nutraceutical may include one or more of a protein, vitamin, fiber, mineral and electrolytes. The composition may be in a powder or fluid form, where the poly-oxygenated aluminum hydroxide is soluble in the fluid.

Claims

1. A composition, comprising:

a poly-oxygenated aluminum hydroxide comprising a clathrate containing oxygen gas molecules that is chlorine-free and soluble in a fluid.

2. The composition as specified in claim 1, further comprising a nutraceutical selected from the group consisting of a protein, a vitamin, fiber, and electrolytes.

3. The composition as specified in claim 1, wherein the poly-oxygenated aluminum hydroxide comprises particles each having a diameter of less than or equal to 212 μ

m.

4. The composition as specified in claim 3, wherein the poly-oxygenated aluminum hydroxide is homogeneous.

5. The composition as specified in claim 1, wherein the poly-oxygenated aluminum hydroxide is configured to be orally delivered and absorbed through lining of a stomach and a small intestine of a mammal.

6. The composition as specified in claim 1, wherein poly-oxygenated aluminum metal hydroxide is configured to be therapeutically effective in treating a condition of a mammal.

7. The composition as specified in claim 1, further comprising a fluid having a concentration of at least 1 milligram of the poly-oxygenated aluminum hydroxide to 8 fluid ounces of the fluid.

8. The composition as specified in claim 1, wherein the poly-oxygenated aluminum hydroxide is configured to not create an immune response of the mammal.

9. The corn position as specified in claim 1, wherein the particles each have a diameter in the range of 107-212 μ

m.

10. The corn position as specified in claim 1, wherein the particles each have a diameter in the range of 46-106 μ

m.

11. The composition as specified in claim 1, wherein the particles each have a diameter in the range of 26-45 μ

m.

12. A composition, comprising:

a poly-oxygenated aluminum hydroxide comprising a clathrate containing oxygen gas molecules that is chlorine-free,

a nutraceutical; and

wherein the composition comprises particles each having a diameter of less than or equal to 212 μ

m.

13. The composition as specified in claim 12 further comprising a fluid, wherein the fluid comprises at least 1 milligram of the poly-oxygenated aluminum hydroxide to 8 fluid ounces of the fluid.

14. The corn position as specified in claim 12, wherein the nutraceutical is selected from the group consisting of a protein, a vitamin, fiber, mineral and electrolytes.

15. The composition as specified in claim 14, wherein the nutraceutical comprises a protein.

16. The composition as specified in claim 14, wherein t e nutraceutical comprises an electrolyte.

17. The composition as specified in claim 12, wherein poly-oxygenated aluminum hydroxide is configured to be therapeutically effective in treating a condition of a mammal.