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Particles for the treatment of cancer in combination with radiotherapy

  • US 10,137,149 B2
  • Filed: 12/08/2010
  • Issued: 11/27/2018
  • Est. Priority Date: 12/09/2009
  • Status: Active Grant
First Claim
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1. A method of treating cancer in a subject comprising:

  • administering a particle to a locus or site of the cancer or to tumour tissue in the subject, which particle comprises a metal oxide, which metal oxide is titanium dioxide doped with from 0.1 to 25 mol % of at least one rare earth element, wherein the titanium dioxide is a host lattice and the at least one rare earth element is present as a dopant within said host lattice; and

    applying X-ray radiation suitable for radiotherapy to the locus or site of the cancer or tumour tissue and thereby exciting the metal oxide in the particle at the locus or site of the cancer or tumour tissue and generating reactive oxygen species at the locus or site of the cancer or tumour tissue.

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