Medical drainage devices with carbon-based structures for inhibiting growth of fibroblasts

• US 10,137,226 B2
• Filed: 05/12/2014
• Issued: 11/27/2018
• Est. Priority Date: 06/16/2009
• Status: Active Grant

• Current Assignee: Mobius Therapeutics, LLC
• Original Assignee: Mobius Therapeutics, LLC
• Inventors: Lafdi, Khalid, Timm, Edward J.
• Primary Examiner(s): Wiest, Philip R
• Application Number:
  US14/275,466
• Publication Number:
  US 20140248454A1
• Time in Patent Office: 1,660 Days
• Field of Search: 604 8
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61L 2400/12 Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
• CPC Class Codes: A61L 29/02 Inorganic materials
• CPC Class Codes: A61L 29/123 having an inorganic matrix
• CPC Class Codes: A61L 29/126 having a macromolecular matrix
• CPC Class Codes: A61L 31/122 of carbon
• CPC Class Codes: A61L 31/125 having a macromolecular matrix
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61M 1/3653 Interfaces between patient blood circulation and extra-corporal blood circuit
• CPC Class Codes: A61M 1/3655 Arterio-venous shunts or fistulae
• CPC Class Codes: A61M 1/84 Drainage tubes; Aspiration tips for negative pressure wound therapy A61M1/90; for surgical cutting instruments A61B17/32
• CPC Class Codes: A61M 11/008 by squeezing, e.g. using a flexible bottle or a bulb
• CPC Class Codes: A61M 2025/0037 characterized by lumina being arranged side-by-side
• CPC Class Codes: A61M 2025/006 having a special surface topography or special surface properties, e.g. roughened or knurled surface
• CPC Class Codes: A61M 2210/101 Pleural cavity
• CPC Class Codes: A61M 25/0009 Making of catheters or other medical or surgical tubes
• CPC Class Codes: A61M 25/001 Forming the tip of a catheter, e.g. bevelling process, join or taper
• CPC Class Codes: A61M 25/0012 with embedded structures, e.g. coils, braids, meshes, strands or radiopaque coils
• CPC Class Codes: A61M 25/0026 Multi-lumen catheters with stationary elements catheter assemblies comprising a catheter in combination with a guide tube, sheath or sleeve A61M2025/0681; catheters comprising telescoping coaxial elements A61M2025/0175
• CPC Class Codes: A61M 25/0043 characterised by structural features
• CPC Class Codes: A61M 27/002 : Implant devices for drainage of body fluids from one part of the body to another intraocular A61F9/00781; middle ear A61F11/202
• CPC Class Codes: A61M 27/006 : Cerebrospinal drainage; Accessories therefor, e.g. valves
• CPC Class Codes: B82Y 5/00 : Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• CPC Class Codes: Y10T 428/1369 : Fiber or fibers wound around each other or into a self-sustaining shape [e.g., yarn, braid, fibers shaped around a core, etc.]
• CPC Class Codes: Y10T 428/23993 : Composition of pile or adhesive

Abstract

Drainage devices for draining a fluid from a patient during treatment of a medical condition body are disclosed. The drainage devices comprise a body defining at least one conduit through the body from a distal end of the body to a proximal end of the body. The body comprises at least one carbon-based structure configured to inhibit growth of fibroblasts in the conduit when the fluid flows through the conduit. Example embodiments of the drainage device may include an ophthalmic shunt, a hydrocephalus shunt, an artificial mesh, an arteriovenous shunt, a thoracic catheter, and a central venous access device.

Claims

1. A composition for use in manufacturing an implantable medical device, having a body with an opening therethrough defining a fluid path for passage of body fluids therethrough, the composition comprising:

a carbon scaffold consisting essentially fibers combined with a biocompatible polymer; and

a layer of carbon nanotubes grown on the carbon fibers providing a resulting structure and configured to be provided at least on inner walls defining the body of the implantable medical device, the resulting structure forming a carbon fuzzy veil;

wherein;

the carbon fuzzy veil resulting from the carbon nanotubes grown on the carbon scaffold is fibroblast-inhibiting relative to a carbon scaffold alone.

2. The composition of claim 1, wherein the carbon fuzzy veil has a ragged microscopic structure.

3. The composition of claim 1, wherein the biocompatible polymer is selected from polymethylmethacrylate and polycarbosilane.

4. The composition of claim 1, further comprising a coating on the carbon fuzzy veil, wherein the coating comprises a flexible polymer.

5. The composition of claim 4, wherein the flexible polymer comprises a biocompatible polymer.

6. The composition of claim 4, wherein the flexible polymer comprises polymethylmethacrylate.

7. The composition of claim 1, wherein the carbon scaffold comprises a structure selected from the group consisting of:

a carbon fiber veil, a carbon fiber-fiber tissue, and a carbon-fiber mat.

8. An implantable medical device comprising the composition of claim 1, the medical device having a body with an opening therethrough defining a fluid path for passage of a body fluid, the body having inner walls facing the opening, wherein the composition lines the inner walls so that the carbon fuzzy veil is in communication with a body fluid passing through the opening.

9. The implantable medical device of claim 8, wherein the composition forms the body of the medical device.

10. The implantable medical device of claim 8, wherein the device is selected from the group consisting of:

a surgical mesh, an arteriovenous shunt, a catheter, an ophthalmic shunt, a hydrocephalus shunt, and a venous access device.

11. A flexible composite for use in manufacturing an implantable medical device having a body with an opening therethrough defining a fluid path through the body, for passage of body fluids, the body having inner walls facing the opening, the flexible composite comprising:

a flexible carbon scaffold consisting essentially of carbon fibers combined with a biocompatible polymer; and

a layer of carbon nanotubes grown on the carbon fibers providing a resulting structure and configured to be provided at least on inner walls defining the body of the implantable medical device, the resulting structure forming a carbon fuzzy veil;

wherein the carbon fuzzy veil resulting from the carbon nanotubes grown on the carbon scaffold is fibroblast-inhibiting relative to a carbon scaffold alone, and wherein the flexible composite is conformal to the inner walls.

12. The flexible composite of claim 11, wherein the carbon fuzzy veil has a ragged microscopic structure.

13. The flexible composite of claim 11, wherein the biocompatible polymer is selected from polymethylmethacrylate and polycarbosilane.

14. The flexible composite of claim 11, further comprising a coating on the carbon fuzzy veil, wherein the coating comprises a flexible polymer.

15. The composition of claim 14, wherein the flexible polymer comprises a biocompatible polymer.

16. The flexible composite of claim 14, wherein the flexible polymer comprises polymethylmethacrylate.

17. The flexible composite of claim 11, wherein the carbon scaffold comprises a structure selected from the group consisting of:

a carbon fiber veil, a carbon fiber-fiber tissue, and a carbon-fiber mat.

18. An implantable medical device comprising the flexible composite of claim 11, wherein the flexible composite lines the inner walls so that the carbon fuzzy veil is in communication with the body fluids passing through the opening.

19. The implantable medical device of claim 18, wherein the device is selected from the group consisting of:

a surgical mesh, an arteriovenous shunt, a catheter, an ophthalmic shunt, a hydrocephalus shunt, and a venous access device.

20. A method for inhibiting fibroblast growth associated with the implantation of a medical drainage device in a subject, wherein the medical drainage device comprises a body having an opening defining a fluid path therethrough and inner walls configured for communication with body fluids passing through the opening, the method comprising:

coating at least the inner walls of the medical drainage device with a composition comprising;

a carbon scaffold consisting essentially of carbon fibers combined with a biocompatible polymer; and

a layer of carbon nanotubes grown on the carbon fibers providing a resulting structure and configured to be provided at least on inner walls defining the body of the implantable medical device, the resulting structure forming a carbon fuzzy veil,

wherein the carbon fuzzy veil resulting from the carbon nanotubes grown on the carbon scaffold is fibroblast-inhibiting relative to a carbon scaffold alone.

21. The method of claim 20, wherein the carbon fuzzy veil has a ragged microscopic structure.

22. The method of claim 20, wherein the biocompatible polymer is selected from polymethylmethacrylate and polycarbosilane.

23. The method of claim 20, further comprising a coating on the carbon fuzzy veil, wherein the coating comprises a flexible polymer.

24. The method of claim 23, wherein the flexible polymer comprises a biocompatible polymer.

25. The method of claim 23, wherein the flexible polymer comprises polymethylmethacrylate.

26. The method of claim 20, wherein the carbon scaffold comprises a structure selected from the group consisting of:

a carbon fiber veil, a carbon fiber-fiber tissue, and a carbon-fiber mat.

27. The method of claim 20, wherein the device is selected from the group consisting of:

a surgical mesh, an arteriovenous shunt, a catheter, an ophthalmic shunt, a hydrocephalus shunt, and a venous access device.