Axial lengthening thrombus capture system

• US 10,143,482 B2
• Filed: 12/18/2017
• Issued: 12/04/2018
• Est. Priority Date: 08/06/2015
• Status: Active Grant

• Current Assignee: Vascular Medcure Incorporated (Medtronic Plc)
• Original Assignee: KP Medcure, Inc.
• Inventors: Nguyen, Thanh Van, Nguyen, Duy, Ngo, Tung Hoang
• Primary Examiner(s): Woo, Julian W
• Application Number:
  US15/845,086
• Publication Number:
  US 20180125512A1
• Time in Patent Office: 351 Days
• CPC Class Codes: A61B 17/221 Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions surgical snare instruments A61B17/32056
• CPC Class Codes: A61B 17/320758 with a rotating cutting instrument, e.g. motor driven A61B17/320725, A61B17/32075 and A61B17/320783 take precedence; for removing intra-ocular material A61F9/00763; endoscopic rotatable cutting instruments A61B17/32002
• CPC Class Codes: A61B 2017/00867 shape memory effect
• CPC Class Codes: A61B 2017/00871 polymeric
• CPC Class Codes: A61B 2017/00893 pharmaceutically effective
• CPC Class Codes: A61B 2017/00938 hydrophobic
• CPC Class Codes: A61B 2017/00942 hydrophilic
• CPC Class Codes: A61B 2017/22038 with a guide wire
• CPC Class Codes: A61B 2017/22079 with suction of debris
• CPC Class Codes: A61B 2017/22081 Treatment of vulnerable plaque
• CPC Class Codes: A61B 2017/22084 stone- or thrombus-dissolving
• CPC Class Codes: A61B 2017/2212 having a closed distal end, e.g. a loop
• CPC Class Codes: A61B 2017/2217 single wire changing shape to a gripping configuration
• CPC Class Codes: A61B 2017/320052 Guides for cutting instruments
• CPC Class Codes: A61B 2017/320716 comprising means for preventing embolism by dislodged material
• CPC Class Codes: A61B 2017/320775 Morcellators, impeller or propeller like means
• CPC Class Codes: A61F 2/011 Instruments for their placement or removal
• CPC Class Codes: A61F 2/013 Distal protection devices, i.e. devices placed distally in combination with another endovascular procedure, e.g. angioplasty or stenting
• CPC Class Codes: A61F 2002/016 made from wire-like elements

Abstract

Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism (PE), deep vein thrombosis (DVT), cerebrovascular embolism, and other vascular occlusions.

Claims

1. A method of retrieving a thrombus, comprising:

accessing an interior of a blood vessel;

advancing an expanding guiding catheter and a shape memory body through the blood vessel, wherein the shape memory body comprises a first end, a second end, and an axial length therebetween;

positioning the expanding guiding catheter and the shape memory body such that the expanding guiding catheter is proximal to the thrombus and the first end of the shape memory body is distal to the thrombus;

expanding the first end of the shape memory body distal to the thrombus while the second end and a majority of the shape memory body remains compressed, wherein the second end is positioned proximal to the first end, wherein the shape memory body comprises a first expanded axial length;

adjusting the shape memory body wherein the shape memory body has a second expanded axial length greater than the first expanded axial length to capture the thrombus; and

retracting the shape memory body proximally and through a funnel opening of the expanding guiding catheter.

2. The method of claim 1, further comprising isolating the thrombus within the shape memory body.

3. The method of claim 1, wherein a first width along the first expanded axial length and a second width of the shape memory body along the second expanded axial length are substantially the same.

4. The method of claim 1, wherein a distal end of the shape memory body is distal to the first end when the first end is expanded.

5. The method of claim 1, further comprising suctioning, macerating, and/or mechanically removing the thrombus.

6. The method of claim 1, further comprising axially lengthening the shape memory body distally after adjusting the shape memory body.

7. The method of claim 1, further comprising radially shortening the shape memory body to compress the thrombus after adjusting the shape memory body.

8. A method of retrieving a thrombus, comprising:

accessing an interior of a blood vessel;

advancing an expanding guiding catheter and a shape memory body through the blood vessel, the shape memory body comprising a first end, a second end, and an axial length therebetween;

positioning the expanding guiding catheter such that a distal end of the expanding guiding catheter is proximal to the thrombus;

advancing the shape memory body through the expanding guiding catheter;

positioning the shape memory body such that a distal end of the shape memory body is distal to the thrombus, the first end and the second end proximal to the distal end, the shape memory body having a first axial length;

axially lengthening the shape memory body to have a second axial length to at least partially capture the thrombus; and

retracting the thrombus into the expanding guiding catheter.

9. The method of claim 8, further comprising expanding a funnel tip proximal to the thrombus.

10. The method of claim 8, wherein the width of the shape memory body is substantially similar when adjusting between the first axial length and the second axial length.

11. The method of claim 8, wherein the shape memory body lengthens distally to create additional space within the shape memory body.

12. The method of claim 8, wherein the thrombus is redistributed within the shape memory body.

13. The method of claim 8, wherein the thrombus is redistributed to facilitated retrieval by the expanding guiding catheter.

14. The method of claim 8, wherein the shape memory body stretches axially and compresses radially to squeeze the thrombus radially and decrease the diameter or width of the thrombus.

15. The method of claim 8, wherein the shape memory body lengthens serially from the distal end to create additional length and space within the shape memory body.

16. The method of claim 8, wherein accessing the interior of the blood vessel further comprises accessing a pulmonary artery to treat a pulmonary embolism.

17. A method of retrieving a thrombus, comprising:

accessing the interior of a blood vessel;

advancing an expanding guiding catheter through the blood vessel;

positioning the expanding guiding catheter such that a distal end of the expanding guiding catheter is proximal to a thrombus;

retracting an outer member of the expanding guide catheter to expand a funnel tip and expose an expandable inner member;

advancing a thrombus capture device comprising a capture assembly through the expanding guide catheter;

positioning the thrombus capture device such that a distal end of the thrombus capture device is distal to or within the thrombus;

actuating the capture assembly to isolate the thrombus within the thrombus capture device, wherein the capture assembly is movable from a first configuration having a first axial length and a second configuration having a second axial length, the second axial length being different from the first axial length, wherein the width of the capture assembly does not substantially change from the first configuration to the second configuration;

axially lengthening the thrombus capture device distally and retracting the thrombus into the funnel tip of the expanding guide catheter;

radially shortening the thrombus capture device to compress the thrombus and promote removal of the thrombus; and

retracting the capture assembly with the thrombus into the funnel tip and the expandable inner member.