×

Controlled irreversible electroporation

  • US 10,143,512 B2
  • Filed: 04/06/2015
  • Issued: 12/04/2018
  • Est. Priority Date: 11/19/2009
  • Status: Active Grant
First Claim
Patent Images

1. A method of targeting cancer cells, comprising the steps of:

  • (a) identifying cancer cells to be ablated in a target area, wherein the target area comprises heterogenous tissue comprising nerve tissue surrounded by myelin layers;

    (b) placing a first electrode and a second electrode such that the target area is positioned between the first and second electrodes;

    (c) applying electrical pulses between the first and second electrodes in an amount which compensates for tissue heterogeneity, and is sufficient to irreversibly electroporate the cancer cells in the target area;

    wherein voltage, wattage and duration of the electrical pulses are maintained within ranges which avoid damage to the nerve tissue in the target area; and

    (d) monitoring temperature of the heterogeneous tissue and adjusting the electrical pulses to maintain the temperature at 50°

    C. or less for a period of time that avoids thermal damage to cells of the heterogeneous tissue.

View all claims
  • 1 Assignment
Timeline View
Assignment View
    ×
    ×