Cardiovascular prostheses

• US 10,143,778 B2
• Filed: 12/21/2016
• Issued: 12/04/2018
• Est. Priority Date: 12/21/2010
• Status: Active Grant

• Current Assignee: Elutia Med LLC
• Original Assignee: Cormatrix Cardiovascular, Inc.
• Inventors: Matheny, Robert G
• Primary Examiner(s): Zhang, Yanzhi
• Application Number:
  US15/386,640
• Publication Number:
  US 20170100515A1
• Time in Patent Office: 713 Days
• Field of Search: 424400
• CPC Class Codes: A61F 2/00 Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents as cosmetic articles, see the relevant subclasses, e.g. wigs, hair pieces, A41G3/00, A41G5/00; artificial nails A45D31/00; dental prostheses A61C13/00; materials for prostheses A61L27/00; artificial hearts A61M60/00; artificial kidneys A61M1/14
• CPC Class Codes: A61F 2/0095 Packages or dispensers for prostheses or other implants for intraocular lenses A61F2/1691; for dental surgery A61C19/02
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61K 31/4418 having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
• CPC Class Codes: A61L 2300/414 Growth factors
• CPC Class Codes: A61L 2430/20 for reconstruction of the heart, e.g. heart valves
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/3633 Extracellular matrix [ECM]
• CPC Class Codes: A61L 27/3834 Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
• CPC Class Codes: A61L 27/507 for artificial blood vessels apparatus for applying cells on a blood vessel prosthesis A61F2/062
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body

Abstract

Cardiovascular prostheses for treating, reconstructing and replacing damaged or diseased cardiovascular tissue that are formed from acellular extracellular matrix (ECM). The cardiovascular prostheses comprise various compositions, such as ECM based compositions, and structures, such as particulate structures, mesh constructs, encasement structures, coated structures and multi-sheet laminate structures.

Claims

1. A vascular graft for treating damaged or diseased tissue, comprising:

a sheet member comprising top and bottom surfaces, and an outer coating layer disposed on said sheet member top surface, said outer coating layer comprising poly(glycerol sebacate) (PGS),

said sheet member consisting of an exosome augmented composition consisting of acellular ECM derived from mammalian tissue source selected from the group consisting of small intestine submucosa (SIS), mesothelial tissue, placental tissue and cardiac tissue and a plurality of exogenous exosomes derived from mesenchymal stem cells (MSCs),

said sheet member, when disposed proximate damaged tissue, being adapted to reduce an inflammatory phase of said damaged tissue and, thereby, reduce an inflammatory response thereof, whereby said sheet member induces enhanced, stem cell proliferation, neovascularization, remodeling of said damaged tissue, and regeneration of new tissue and tissue structures with site specific structural and functional properties, compared to induced stem cell proliferation, neovascularization, remodeling, and regeneration of new tissue and tissue structures by an ECM sheet member consisting solely of acellular mammalian ECM,

said coated top surface of said sheet member, when disposed proximate said damaged tissue, being adapted to adhere to said damaged tissue, degrade and exhibit a linear degradation profile.