Systems and methods for implantable leadless tissue stimulation

• US 10,143,850 B2
• Filed: 08/29/2016
• Issued: 12/04/2018
• Est. Priority Date: 06/20/2006
• Status: Active Grant

• Current Assignee: EBR Systems, Inc.
• Original Assignee: EBR Systems, Inc.
• Inventors: Cowan, Mark W., Riley, Richard E., Brisken, Axel F., Echt, Debra S.
• Primary Examiner(s): Bertram, Eric D.
• Application Number:
  US15/250,897
• Publication Number:
  US 20160367823A1
• Time in Patent Office: 827 Days
• CPC Class Codes: A61N 1/326 for promoting growth of cells, e.g. bone cells
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control
• CPC Class Codes: A61N 1/36021 for treatment of pain
• CPC Class Codes: A61N 1/36038 Cochlear stimulation
• CPC Class Codes: A61N 1/3604 for correcting spinal deformities, e.g. scoliosis
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/37217 characterised by the communication link, e.g. acoustic or tactile
• CPC Class Codes: A61N 1/37288 Communication to several implantable medical devices within one patient
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators
• CPC Class Codes: A61N 1/3787 from an external energy source

Abstract

Systems and methods are disclosed to stimulate tissue to treat medical conditions involving tissues such as the bone, spine, stomach, nerves, brain and the cochlea. The disclosed invention uses electrical stimulation of the tissue, where vibrational (or acoustic) energy from a source is received by an implanted device and converted to electrical energy and the converted electrical energy is used by implanted electrodes to stimulate the pre-determined tissue sites. The vibrational energy is generated by a controller-transmitter, which could be either implanted or located externally. The vibrational energy is received by a receiver-stimulator, which could be located at or close to the stimulation site.

Claims

1. A method for stimulating tissue, comprising:

transmitting acoustic energy and signal information using an acoustic controller-transmitter;

receiving said acoustic energy and signal information by an implantable acoustic receiver-stimulator having electrode assembly adapted to be in direct contact with the tissue;

converting the received acoustic energy to electrical energy by the receiver-stimulator to provide electrical stimulation output to the tissue;

sensing the electrical stimulation output of the receiver-stimulator using one or more sensors disposed on an external surface of the controller-transmitter, and

adjusting acoustic transmission from the acoustic controller-transmitter based on the sensed electrical stimulation output in order to compensate for changes in the electrical stimulation output.

2. The method of claim 1, wherein the tissue is chosen from the list of bone, spine, nerves, gastrointestinal tract, brain or cochlea.

3. The method of claim 1, wherein the controller-transmitter operation is controlled by the patient.

4. The method of claim 1, wherein the controller-transmitter is programmed to treat continuous pain.

5. The method of claim 1, wherein the tissue is the nerve.

6. The method of claim 5, where stimulating the nerve treats one or more medical conditions chosen from the list comprising headache, facial pain, pelvic pain, heart failure, hypertension, obesity, migraine, neuropsychiatric disorders, urinary, gastrointestinal, urge or stress urinary incontinence, and fecal incontinence.

7. A system for stimulating tissue, comprising:

an acoustic controller-transmitter comprising one or more sensors disposed on an external surface of the controller-transmitter; and

an implantable acoustic receiver-stimulator having an electrode assembly adapted to be in direct contact with the tissue;

wherein the controller-transmitter is adapted to transmit acoustic energy and the receiver-stimulator is adapted to receive acoustic energy and convert said acoustic energy to electrical energy, and the receiver-stimulator is configured to provide electrical stimulation output to the tissue;

wherein the controller-transmitter is configured to periodically sense the electrical stimulation output of the receiver-stimulator using the one or more sensors and adjust acoustic energy transmission accordingly in order to compensate for changes in the electrical stimulation output of the receiver-stimulator.