Dual rotation charged particle imaging / treatment apparatus and method of use thereof

• US 10,143,854 B2
• Filed: 09/09/2016
• Issued: 12/04/2018
• Est. Priority Date: 05/22/2008
• Status: Active Grant

• Current Assignee: ProTom International Holding Corporation
• Original Assignee: ProTom International Holding Corporation
• Inventors: Michaud, Susan L., Raymond, Daniel J., Lee, W. Davis
• Primary Examiner(s): MCCORMACK, JASON L
• Application Number:
  US15/260,763
• Publication Number:
  US 20160375269A1
• Time in Patent Office: 816 Days
• Field of Search: 2504921, 2504923, 2504931
• CPC Class Codes: A61B 6/032 Transmission computed tomography [CT]
• CPC Class Codes: A61B 6/0487 Motor-assisted positioning
• CPC Class Codes: A61B 6/4092 for producing synchrotron radiation
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence
• CPC Class Codes: A61B 6/4266 characterised by using a plurality of detector units A61B6/4014 takes precedence
• CPC Class Codes: A61B 6/50 specially adapted for specific body parts; specially adapted for specific clinical applications
• CPC Class Codes: A61B 6/5205 involving processing of raw data to produce diagnostic data
• CPC Class Codes: A61N 2005/1054 using a portal imaging system
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 2005/1095 Elements inserted into the radiation path within the system, e.g. filters or wedges
• CPC Class Codes: A61N 2005/1097 Means for immobilizing the patient
• CPC Class Codes: A61N 5/1037 taking into account the movement of the target, e.g. 4D-image based planning
• CPC Class Codes: A61N 5/1039 using functional images, e.g. PET or MRI
• CPC Class Codes: A61N 5/1067 in real time, i.e. during treatment
• CPC Class Codes: A61N 5/1069 Target adjustment, e.g. moving the patient support
• CPC Class Codes: A61N 5/107 in real time, i.e. during treatment
• CPC Class Codes: A61N 5/1077 Beam delivery systems
• CPC Class Codes: A61N 5/1081 Rotating beam systems with a specific mechanical construction, e.g. gantries
• CPC Class Codes: A61N 5/1082 having multiple beam rotation axes
• CPC Class Codes: G21K 1/08 Deviation, concentration or focusing of the beam by electric or magnetic means electron-optical arrangements in electric discharge tubes H01J29/46; details, e.g. electric or magnetic deviating means for direct voltage accelerators or in accelerators using single pulses H05H5/02; arrangements for injecting particles into orbits H05H7/08; arrangements for ejecting particles from orbits H05H7/10

Abstract

The invention comprises a method and apparatus for imaging a tumor of a patient using one or more imaging systems positionable about the tumor and treating the tumor using positively charged particles, such as: (1) using a rotatable gantry support to support and rotate a section of a positively charged particle beam transport line about a rotation axis and a tumor of a patient; (2) using a rotatable and optionally extendable secondary support to support, circumferentially position, and laterally position a primary and optional secondary imaging system about the tumor; (3) image the tumor using the primary and optional secondary imaging system as a function of rotation and/or translation of the secondary support; and (4) treat, optionally concurrently with imaging, the tumor using the positively charged particles as a function of circumferential position of the section of the charged particle beam about the tumor.

Claims

1. A method for treating a tumor of a patient with positively charged particles, comprising the steps of:

using a gantry to support a portion of a charged particle beam transport line;

rotating a rotatable gantry support about a rotation axis, said rotatable gantry support connected to said gantry, wherein said step of rotating rotates said gantry and said portion of said charged particle beam transport line about the patient;

providing a primary imaging system connected to a rotatable secondary support, said primary imaging system comprising;

a source system element; and

a detection system element;

rotating said rotatable secondary support, wherein said step of rotating said rotatable secondary support rotates at least said source system element and said detection system element about the tumor;

imaging the tumor, as a function of rotation position of said rotatable secondary support, using said primary imaging system, said step of imaging further comprising the step of;

using said source system element and said detection system element to image the tumor, said source system element comprising at least a portion of an X-ray source system;

treating the tumor, as a function of rotation position of said gantry, using the positively charged particles transported through said charged particle beam transport line;

using a controller to independently rotate, about the patient;

(1) said rotatable gantry support supporting said portion of said charged particle beam transport line and (2) said rotatable secondary support supporting said source system element and said detection system element of said primary imaging system;

extending a first extension section of said rotatable secondary support to position a portion of a secondary source system on a first side of the patient; and

extending a second extension section of said rotatable secondary support to position a portion of a secondary detection system on a second side of the patient.

2. The method of claim 1, further comprising the step of:

during said step of imaging, treating the tumor using the positively charged particles transported along said charged particle beam transport line.

3. The method of claim 1, further comprising the steps of:

providing a patient support;

positioning the patient on said patient support;

after said step of imaging, translating said patient support, while supporting the patient, along the rotation axis;

said step of translating moving the tumor into a treatment beamline of the positively charged particles; and

treating the tumor using the positively charged particles, said treatment beamline passing from an accelerator, through an exit nozzle, and into the tumor.

4. The method of claim 1, further comprising the step of:

imaging the tumor as a function of extension position of said second extension section, said secondary detection system comprising a detector system sub-component of a positron emission tomography system.

5. The method of claim 4, further comprising the step of:

using tomographic reconstruction to generate a three dimensional image of the tumor using;

(1) output of an X-ray detector system linked to said X-ray source system and (2) output of said positron emission tomography system.

6. The method of claim 1, further comprising the step of:

concurrent with use of said X-ray source system, collecting at least one tomogram of the tumor using the positively charged particle beam, a scintillation material, and a scintillation detector.

7. The method of claim 6, said scintillation detector comprising:

a first two-dimensional detector array comprising a detection face; and

a second two-dimensional detector array comprising a detection surface, said detection face and said detection surface defining an angle of ten to one hundred seventy degrees.

8. An apparatus for treating a tumor of a patient with positively charged particles, comprising:

a portion of a charged particle beam transport line supported by a gantry;

a rotatable gantry support, rotatable about a rotation axis, connected to said gantry, wherein rotation of said rotatable gantry support rotates said gantry and said portion of said charged particle beam transport line about the patient during use; and

a primary imaging system comprising a source system element and a detection system element, said primary imaging system connected to a rotatable secondary support, wherein rotation of said rotatable secondary support rotates at least said source system element and said detection system element about the tumor during use, said rotatable secondary support further comprising;

an alternately extendable and retractable first side rail attached to said rotatable secondary support; and

an alternately extendable and retractable second side rail attached to a rotationally opposite side of said rotatable secondary support from said first side rail,

said source system element attached to said first side rail,

said detection system element attached to said second side rail, and

said rotatable gantry support configured to circumferentially rotate said first side rail and said second side rail around the patient during use at both a first extension position and a second extension position of said first side rail and said second side rail,

wherein said primary imaging system images the tumor, as a function of rotation of said rotatable secondary support, during use,

wherein the positively charged particles, passing through said charged particle beam transport line, treat the tumor as a function of rotation position of said gantry during use.

9. The apparatus of claim 8, said rotatable secondary support comprising:

a first rail connected to said source system element; and

a second rail connected to said detection system element.

10. The apparatus of claim 9, further comprising:

a portion of said rotatable secondary support positioned inside said rotatable gantry support.

11. The apparatus of claim 10, said first rail connected to and co-rotatable with said rotatable gantry support, said second rail connected to and co-rotatable with said rotatable gantry support.

12. The apparatus of claim 9, said first rail connected to said rotatable secondary support, said second rail connected to said rotatable secondary support, said rotatable gantry support and said rotatable secondary support independently rotatable.

13. The apparatus of claim 9, said rotatable secondary support further comprising:

a tertiary imaging support axis translatable along the rotation axis.

14. The apparatus of claim 8, further comprising:

a vertically translatable support;

said detection system element of said primary imaging system connected to said translatable support, said vertically translatable support configured to move said detection system element.

15. The apparatus of claim 14, said detection element comprising an element of a positron emission tomography system.