Systems and methods for dispensing radioactive liquids

• US 10,144,537 B2
• Filed: 11/30/2016
• Issued: 12/04/2018
• Est. Priority Date: 11/30/2016
• Status: Active Grant

• Current Assignee: Curium US LLC
• Original Assignee: Mallinckrodt Nuclear Medicine LLC (Mallinckrodt plc)
• Inventors: Graves, Kevin B., Petrofsky, Bryan S., Morton, Brian J., Muraczewski, Matthew S., Lindskog, Lars, Iverson, Stephen C., Martinez, Rafael A.
• Primary Examiner(s): Warden, Jill A
• Assistant Examiner(s): Handy, Dwayne K
• Application Number:
  US15/365,279
• Publication Number:
  US 20180148200A1
• Time in Patent Office: 734 Days
• CPC Class Codes: A61M 5/178 Syringes
• CPC Class Codes: B65B 3/003 Filling medical containers such as ampoules, vials, syringes or the like
• CPC Class Codes: B65B 3/12 mechanically, e.g. by pistons or pumps
• CPC Class Codes: B67D 7/02 for transferring liquids other than fuel or lubricants
• CPC Class Codes: G21F 5/015 for storing radioactive sources, e.g. source carriers for irradiation units; Radioisotope containers
• CPC Class Codes: G21F 5/14 Devices for handling containers or shipping-casks, e.g. transporting devices loading and unloading, filling of containers cranes, load-engaging elements or devices for cranes, capstans, winches or tackles B66C
• CPC Class Codes: G21F 7/068 Remotely manipulating devices for fluids
• CPC Class Codes: G21G 1/0005 Isotope delivery systems use of radioisotopes as tracers G21H5/02

Abstract

Systems and methods for dispensing radioactive liquids using a liquid dispensing apparatus are described. The apparatus includes a support arm rotatable about a rotation axis, an actuator operatively connected to the support arm and configured to at least one of rotate the support arm about the rotation axis and displace the support arm in a direction parallel to the rotation axis, and a pipette assembly mounted to the support arm. The pipette assembly includes a pipette tip defining an opening through which liquids are aspirated and dispensed, a piston, and a stepper motor operatively connected to the piston to control linear displacement of the piston.

Claims

1. A system for dispensing radioactive liquids, the system comprising:

a radiation containment chamber including an enclosure constructed of a radiation shielding material; and

a liquid dispensing apparatus at least partly disposed in an interior of the enclosure, the liquid dispensing apparatus including;

a support arm rotatable about a rotation axis;

an actuator operatively connected to the support arm and configured to at least one of rotate the support arm about the rotation axis and displace the support arm in a direction parallel to the rotation axis;

a pipette assembly mounted to the support arm, the pipette assembly including a pipette tip defining an opening through which liquids are aspirated and dispensed, a piston, and a stepper motor operatively connected to the piston to control linear displacement of the piston;

a controller connected to the stepper motor and configured to control the stepper motor to control displacement of the piston, wherein the controller is configured to determine a number of steps by which to rotate the stepper motor based on a non-linear relationship between a volume of liquid aspirated or dispensed by the pipette assembly and a corresponding number of steps by which the stepper motor is rotated.

2. The system of claim 1, wherein the controller is positioned outside of the radiation containment chamber.

3. The system of claim 2, wherein the controller is further configured to:

receive an input associated with a target transfer volume;

determine a number of steps by which to rotate the stepper motor based on the input; and

control a supply of current to the stepper motor based on the determined number of steps to rotate the stepper motor by the determined number of steps.

4. The system of claim 2, wherein the stepper motor is a first stepper motor, and wherein the actuator includes a second stepper motor operatively connected to the support arm to displace the support arm in a direction parallel to the rotation axis, wherein the controller is further configured to:

control the second stepper motor to position the pipette tip at a first height;

control the first stepper motor to displace the piston and aspirate a first volume of radioactive liquid from a vial while the pipette tip is positioned at the first height;

control the second stepper motor to position the pipette tip at a second height lower than the first height; and

control the first stepper motor to displace the piston and aspirate a second volume of radioactive liquid from the vial while the pipette tip is positioned at the second height.

5. The system of claim 1, wherein the stepper motor is a first stepper motor, and wherein the actuator includes a second stepper motor operatively connected to the support arm and configured to rotate the support arm about the rotation axis, and a third stepper motor operatively connected to the support arm and configured to displace the support arm in a direction parallel to the rotation axis.

6. The system of claim 5 further comprising a support frame including a base and a column extending vertically upward from the base, wherein the second and third stepper motors are positioned within an interior of the column.

7. The system of claim 5, wherein the second and third stepper motors are operatively connected to the support arm through a rotatable shaft, wherein operation of the second stepper motor rotates the shaft, and wherein operation of the third stepper motor displaces the shaft in the direction parallel to the rotation axis, wherein rotation of the rotatable shaft causes the support arm to rotate about the rotation axis, and wherein displacement of the shaft causes the support arm to move in the direction parallel to the rotation axis.

8. The system of claim 1 further comprising a first vial assembly and a second vial assembly, wherein each of the first and second vial assemblies include a vial and a radiation shield at least partially enclosing the vial, and wherein the actuator is configured to rotate the support arm such that the pipette assembly is movable between a first position, in which the pipette assembly is positioned to aspirate a liquid from the vial of the first vial assembly, and a second position, in which the pipette assembly is positioned to dispense the liquid into the vial of the second vial assembly.

9. The system of claim 8, wherein at least one of the vials of the first and second vial assemblies contains a radioactive liquid.

10. The system of claim 9, wherein the radioactive liquid includes one of Germanium-68, Strontium-87m, Technetium-99m, Indium-111m, Iodine-131, and Thallium-201.

11. An apparatus for dispensing radioactive liquids, the apparatus comprising:

a support arm rotatable about a rotation axis;

an actuator operatively connected to the support arm, the actuator including a second stepper motor and a third stepper motor, the second stepper motor operatively connected to the support arm and configured to rotate the support arm about the rotation axis, the third stepper motor operatively connected to the support arm and configured to displace the support arm in a direction parallel to the rotation axis; and

a pipette assembly mounted to the support arm, the pipette assembly including a pipette tip defining an opening through which liquids are aspirated and dispensed, a piston, and a first stepper motor operatively connected to the piston to control linear displacement of the piston;

wherein the apparatus is free of radiation-sensitive electronics.

12. The apparatus of claim 11, wherein the apparatus is capable of operating for at least 10 cumulative hours within a high radiation area.

13. The apparatus of claim 11, wherein the apparatus is capable of operating for at least 10 cumulative hours in a radioactive field of 5 million millirems per hour.

14. The apparatus of claim 11, wherein the pipette assembly has a dispense capacity of at least 1.0 mL and a dispense tolerance better than +/−

5.0% of a target volume over a dispense range of 0.1 mL to 1.0 mL.

15. The apparatus of claim 11, wherein the pipette assembly has a dispense capacity of at least 4.0 mL and a dispense tolerance better than +/−

2.0% of a target volume over a dispense range of 0.1 mL to 4.0 mL.

16. The apparatus of claim 11, further comprising a support frame including a base and a column extending vertically upward from the base, wherein the second and third stepper motors are positioned within an interior of the column.

17. A method of dispensing radioactive liquid using a dispensing apparatus including a pipette assembly mounted on a rotatable support arm, the pipette assembly including a pipette tip, a piston, a controller, and a stepper motor operatively connected to the piston, the method comprising:

positioning the pipette assembly above a first vial using the support arm;

aspirating a volume of radioactive liquid from a first vial by displacing the piston in a first direction using the stepper motor;

determining, using the controller, a number of steps by which to rotate the stepper motor based on a non-linear relationship between a volume of liquid aspirated or dispensed by the pipette assembly and a corresponding number of steps by which the stepper motor is rotated;

rotating the support arm to position the pipette assembly above a second vial; and

dispensing at least a portion of the volume of radioactive liquid into the second vial by displacing the piston in a second direction opposite the first direction using the stepper motor.

18. The method of claim 17, further comprising receiving, at the controller connected to the stepper motor, an input associated with a target transfer volume, wherein aspirating a volume of radioactive liquid from the first vial includes controlling, using the controller, a supply of current to the stepper motor based on the input to displace the piston in the first direction.

19. The method of claim 18, further comprising:

controlling, using the controller, the supply of current to the stepper motor based on the determined number of steps.

20. The method of claim 17, wherein aspirating a volume of radioactive liquid from the first vial includes:

aspirating a first volume of radioactive liquid while the pipette tip is positioned at a first distance from a bottom of the first vial;

lowering the pipette to a second distance from the bottom of the first vial; and

aspirating a second volume of radioactive liquid while the pipette tip is positioned at the second distance from the bottom of the first vial.