Compositions and methods for diagnosing and monitoring hyperthyroidism in a feline
First Claim
1. A method of treating a feline suffering from hyperthyroidism, the method comprising:
- measuring an increase of at least a three fold change in the level of expression of one or more biomarkers in a blood sample from a feline relative to a control value for expression in a sample from a normal feline or population of felines, and/or relative to a previous individual baseline value from the feline; and
treating the feline by dietary and/or pharmaceutical intervention,wherein the one or more biomarkers exhibiting the increase in the level of expression comprises IYD.
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Abstract
The present invention provides a method of diagnosing the existence or risk of hyperthyroidism in a feline comprising measuring the level of expression of one or more biomarkers selected from the group consisting of e.g., IYD, TG, SLC5A5, NIS, TPO, TSHR, DUOX1, DUOX2 (ThOX), TGFB1, CSTD, DCN and SEPP1 and the expression products thereof, in a biological sample from the feline, wherein elevated expression of the one or more biomarkers in the sample relative to a control value for expression in a sample from a normal feline or feline population, or a baseline value from the feline, indicates the existence or risk of hyperthyroidism; a method of treating a feline so diagnosed; and compositions, reagents and kits for carrying out the specified methods.
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Citations
9 Claims
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1. A method of treating a feline suffering from hyperthyroidism, the method comprising:
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measuring an increase of at least a three fold change in the level of expression of one or more biomarkers in a blood sample from a feline relative to a control value for expression in a sample from a normal feline or population of felines, and/or relative to a previous individual baseline value from the feline; and treating the feline by dietary and/or pharmaceutical intervention, wherein the one or more biomarkers exhibiting the increase in the level of expression comprises IYD. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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Specification