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System and method for assessing treatment effects on obstructive sleep apnea

  • US 10,149,621 B2
  • Filed: 08/03/2014
  • Issued: 12/11/2018
  • Est. Priority Date: 02/11/2014
  • Status: Active Grant
First Claim
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1. A method of assessing treatment effects on obstructive sleep apnea, the method comprising:

  • (a) measuring each of an electrocardiogram and respiratory rhythm of a patient using a bio-signal measurement unit comprised of an electrocardiogram measurement unit measuring the electrocardiogram and a respiratory rhythm measurement unit which is different from the electrocardiogram measurement unit and measures the respiratory rhythm;

    (b) obtaining, with a combined index calculation unit comprised of a heart rate variability entropy calculation unit, a respiratory rhythm entropy calculation unit, and a cross-sample entropy calculation unit, a combined cardiac and respiratory index by combining heart rate variability and respiratory rhythm signals, measured at the step (a), the obtaining comprises;

    (b-1) calculating heart rate variability sample entropy (SampEnRR) using the heart rate variability entropy calculation unit, and calculating respiratory rhythm sample entropy (SampEnrep) using the respiratory rhythm entropy calculation unit; and

    (b-2) obtaining the combined cardiac and respiratory index (Cross-SampEn) by combining the heart rate variability sample entropy with the respiratory rhythm sample entropy using the cross-sample entropy calculation unit;

    (c) assessing, with a treatment response assessment unit, a response of the patient to treatment of obstructive sleep apnea by using the combined cardiac and respiratory index,wherein an abnormality in central autonomic regulation is quantified and a response of a patient to continuous positive airway pressure (CPAP) is quantified based on the combined cardiac and respiratory index,wherein the step (c) comprises;

    assessing the treatment effects on obstructive sleep apnea based on a change in the combined cardiac and respiratory index or a difference of the combined cardiac and respiratory index from that of a normal control; and

    determining that the coordination between heart rate and respiratory rhythm is low if a value of the combined cardiac and respiratory index is higher than an upper limit of a normal range, and determining that the coordination between heart rate and respiratory rhythm is high if the value of the combined cardiac and respiratory index is lower than a lower limit of the normal range,wherein the heart rate variability sample entropy and the respiratory rhythm sample entropy at the step (b) are calculated using density correlation functions Ci,m(r) Ci,(m+1)(r);

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