Device for in vivo sampling of biological species

• US 10,149,668 B2
• Filed: 06/30/2014
• Issued: 12/11/2018
• Est. Priority Date: 06/28/2013
• Status: Active Grant

• Current Assignee: Commissariat a L'Energie Atomique (AES Corporation)
• Original Assignee: Commissariat a L'Energie Atomique (AES Corporation)
• Inventors: Bouamrani, Mohamed-Ali, Berger, Francois, Dreyfus, Matthieu, Mombrun, Adrien
• Primary Examiner(s): HINDENBURG, MAX F
• Application Number:
  US14/901,231
• Publication Number:
  US 20160296215A1
• Time in Patent Office: 1,625 Days
• Field of Search: 600572
• CPC Class Codes: A61B 10/02 Instruments for taking cell samples or for biopsy A61B10/0038 and A61B10/0045 take precedence; needle locating or guiding means A61B17/3403; samplers for enzymology or microbiology C12M1/26; sampling or preparing biological specimens G01N33/48
• CPC Class Codes: A61B 10/04 Endoscopic instruments
• CPC Class Codes: A61B 2010/0216 Sampling brushes
• CPC Class Codes: A61B 2017/00358 Snares for grasping
• CPC Class Codes: A61F 13/38 Swabs having a stick-type handle, e.g. cotton tips ear cleaners other than cotton tips A61F11/006; swabs containing a liquid, e.g. in a rupturable reservoir, A61M35/006
• CPC Class Codes: A61F 2013/53081 with special pore dimension or arrangement

Abstract

The invention relates to a device for in vivo sampling of biological species, comprising:—a capture medium made from a nanoporous material, having a capture surface for said species, said capture medium being supported by a plate,—a gripping rod,—an articulation comprising a first limb coupled to the gripping rod and a second limb coupled removably to the plate supporting the capture medium, such that the capture surface can be selectively oriented relative to the gripping rod, so as to adjust the orientation of the capture medium relative to the gripping rod.

Claims

1. A device for sampling biological material in vivo comprising:

a capture support comprising a nanoporous material, said capture support having a nanoporous surface configured for capturing the biological material from living tissue,

a plate that bears the capture support,

a grasping rod, and

a joint comprising a first member coupled with the grasping rod and a second member removably coupled with the plate bearing the capture support, so that the capture surface is selectively orientable relatively to the grasping rod, so as to adjust the orientation of the capture support relatively to the grasping rod.

2. The device according to claim 1, wherein the first and the second members of the joint may be separated so as to detach the capture support from the grasping rod.

3. The device according to claim 1, wherein the capture support is fitted into the plate, said plate having a rim flush with the capture surface, so that only the capture surface of said support is in contact with tissues during in vivo sampling.

4. The device according to claim 1, wherein the plate is in an electrically conducting material.

5. The device according to claim 1, wherein the joint is a ball joint.

6. The device according to claim 1, wherein the material of the capture support is nanoporous silicon.

7. The device according to claim 1, wherein the capture surface is circular and has a diameter of less than 10 mm.

8. The device according to claim 1, further comprising a device for orienting the capture support, comprising a cable extending along the grasping rod and coupled with the second member of the joint.

11. The device of claim 1, wherein the tissue retains its histological structure.

9. A device for sampling biological material in vivo comprising:

a capture support comprising a nanoporous material, said capture support having a nanoporous surface configured for capturing the biological material from living tissue,

a plate that bears the capture support, said plate being in an electrically conducting material,

a grasping rod, and

a joint comprising a first member coupled with the grasping rod and a second member removably coupled with the plate bearing the capture support, so that the capture surface is selectively orientable relatively to the grasping rod, so as to adjust the orientation of the capture support relatively to the grasping rod,

wherein the tissue retains its histological structure.

10. A device for sampling biological material in vivo comprising:

a capture support comprising a nanoporous material, said capture support having a nanoporous surface configured for capturing the biological material from living tissue,

a plate that bears the capture support,

a grasping rod, and

a joint comprising a first member coupled with the grasping rod and a second member removably coupled with the plate bearing the capture support, so that the capture surface is selectively orientable relatively to the grasping rod, so as to adjust the orientation of the capture support relatively to the grasping rod,

wherein the second member of the joint is coupled with the plate opposite the nanoporous surface of the capture support,

wherein the tissue retains its histological structure.