Compositions and methods for combination ingredient delivery

• US 10,149,822 B2
• Filed: 10/07/2016
• Issued: 12/11/2018
• Est. Priority Date: 02/11/2015
• Status: Active Grant

• Current Assignee: Johnson & Wales University
• Original Assignee: The Fix, LLC
• Inventors: Allio, Michael K., Lane, Stephen, Wo, Marco
• Primary Examiner(s): Arnold, Ernst V
• Assistant Examiner(s): Chang, Kyung S
• Application Number:
  US15/288,583
• Publication Number:
  US 20170020811A1
• Time in Patent Office: 795 Days
• Field of Search: None
• CPC Class Codes: A23G 3/563 products with an inedible support, e.g. a stick
• CPC Class Codes: A23L 2/52 Adding ingredients adding preservatives A23L2/44
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/045 Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
• CPC Class Codes: A61K 31/047 having two or more hydroxy groups, e.g. sorbitol
• CPC Class Codes: A61K 31/05 Phenols cannabinoids A61K31/658
• CPC Class Codes: A61K 31/09 having two or more such linkages
• CPC Class Codes: A61K 31/135 having aromatic rings , e.g. ketamine, nortriptyline methadone A61K31/137
• CPC Class Codes: A61K 31/137 Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
• CPC Class Codes: A61K 31/167 having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• CPC Class Codes: A61K 31/19 Carboxylic acids, e.g. valproic acid salicylic acid A61K31/60
• CPC Class Codes: A61K 31/192 having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid cannabinoids A61K31/658
• CPC Class Codes: A61K 31/194 having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
• CPC Class Codes: A61K 31/245 Amino benzoic acid types, e.g. procaine, novocaine salicylic acid esters A61K31/60
• CPC Class Codes: A61K 31/29 Antimony or bismuth compounds
• CPC Class Codes: A61K 31/4402 only substituted in position 2, e.g. pheniramine, bisacodyl
• CPC Class Codes: A61K 31/4453 only substituted in position 1, e.g. propipocaine, diperodon
• CPC Class Codes: A61K 31/485 Morphinan derivatives, e.g. morphine, codeine
• CPC Class Codes: A61K 31/522 having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• CPC Class Codes: A61K 31/616 : by carboxylic acids, e.g. acetylsalicylic acid
• CPC Class Codes: A61K 31/695 : Silicon compounds
• CPC Class Codes: A61K 31/7004 : Monosaccharides having only carbon, hydrogen and oxygen atoms
• CPC Class Codes: A61K 31/7028 : Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
• CPC Class Codes: A61K 31/80 : Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
• CPC Class Codes: A61K 33/10 : Carbonates; Bicarbonates
• CPC Class Codes: A61K 35/644 : Beeswax; Propolis; Royal jelly; Honey
• CPC Class Codes: A61K 36/185 : Magnoliopsida (dicotyledons)
• CPC Class Codes: A61K 36/28 : Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
• CPC Class Codes: A61K 36/53 : Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
• CPC Class Codes: A61K 36/59 : Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
• CPC Class Codes: A61K 36/73 : Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
• CPC Class Codes: A61K 36/752 : Citrus, e.g. lime, orange or lemon
• CPC Class Codes: A61K 36/899 : Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
• CPC Class Codes: A61K 36/9066 : Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
• CPC Class Codes: A61K 36/9068 : Zingiber, e.g. garden ginger
• CPC Class Codes: A61K 47/46 : Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
• CPC Class Codes: A61K 9/0056 : Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
• CPC Class Codes: A61K 9/0095 : Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006

Abstract

Described herein are compositions, methods, and devices for relief of a cough, cold, sore throat, or allergy, or a related symptom. Also described herein are compositions, methods, and devices for the prevention, treatment and/or amelioration of a digestive illness or digestive discomfort, or a related symptom of either. Such compositions may be in the form of a liquid composition and include a plurality of pharmaceutical ingredients and a plurality of botanical ingredients.

Claims

1. A composition comprising:

a plurality of active pharmaceutical ingredients, wherein the plurality of active pharmaceutical ingredients comprises (i) calcium carbonate and simethicone or (ii) bismuth subsalicylate and simethicone; and

a plurality of botanical ingredients, wherein the plurality of botanical ingredients comprises five of the following;

honey, chamomile, meadowsweet, turmeric, catnip, or lemon, wherein the plurality of active pharmaceutical ingredients and the plurality of botanical ingredients are present in a ratio by weight of 1;

5 to 1;

30, and wherein the composition is in a liquid dosage form.

2. The composition of claim 1, wherein the plurality of botanical ingredients consists of honey, chamomile, meadowsweet, lemon, and turmeric.

3. The composition of claim 1, wherein the catnip is catnip glycerin.

4. The composition of claim 1, wherein the lemon is lemon balm or lemon oil.

5. The composition of claim 1, wherein the chamomile is chamomile flower.

6. The composition of claim 1, wherein the meadowsweet is meadowsweet powder.

7. The composition of claim 1, wherein the plurality of botanical ingredients further comprises oats, marshmallow powder, cinnamon, or ginger.

8. The composition of claim 7, wherein the plurality of botanical ingredients consists of honey, oats, catnip, chamomile, marshmallow powder, meadowsweet, ginger, and turmeric.

9. The composition of claim 7, wherein the cinnamon is cinnamon powder, cinnamon tincture, or cinnamon oil.

10. The composition of claim 7, wherein the ginger is ginger power.

11. The composition of claim 1, wherein the plurality of active pharmaceutical ingredients further comprises alumina powder, calcium gluconate, calcium polycarbophil, carboxymethylcellulose sodium, charcoal, homatropine methylbromide, hyocyamine sulfate, kaolin, lactobacillus acidophilic, lactobacillus bulgaricus, loperamine HCl, opium, paregoric, pectin, phenyl salicylate, psyllium husk, polycarbophil, potassium carbonate, scopolamine hydrobromide, sodium carboxymethylcellulose, zinc phenolsulfonate, dimenhydrinate, meclizine hydrochloride, glutamic acid hydrochloride, acetaminophen, aluminum hydroxide, aspirin, caffeine, fructose, magnesium carbonate, magnesium trisilicate, sodium citrate, or sodium acetylsalicylate.

12. The composition of claim 1, wherein the plurality of active pharmaceutical ingredients and the plurality of botanical ingredients are present in a ratio by weight of 1:

5 to 1;

20.

13. The composition of claim 1, wherein the plurality of active pharmaceutical ingredients and the plurality of botanical ingredients are present in a ratio by weight of 1:

5 to 1;

11.

14. The composition of claim 1, wherein the plurality of active pharmaceutical ingredients and the plurality of botanical ingredients are present in a ratio by weight of about 1:

7.5.

15. The composition of claim 1, further comprising a microstructure which comprises:

the plurality of botanical ingredients, or the plurality of active pharmaceutical ingredients.

16. The composition of claim 1, wherein the liquid dosage form is carbonated or creamy.

17. The composition of claim 1, wherein the plurality of active pharmaceutical ingredients is present in an amount of 1100 mg to 2200 mg.

18. The composition of claim 1, wherein the plurality of botanical ingredients is present in an amount of 12000 mg to 13000 mg.

19. The composition of claim 1, wherein the plurality of active pharmaceutical ingredients is present in an amount of 1100 mg to 2200 mg, and wherein the plurality of botanical ingredients is present in an amount of 12000 mg to 13000 mg.

20. The composition of claim 1, wherein the plurality of active pharmaceutical ingredients is present in an amount of about 1625 mg, and wherein the plurality of botanical ingredients is present in an amount of about 12255 or about 12700 mg.