Bismuth-containing compounds, coordination polymers, methods for modulating pharmacokinetic properties of biologically active agents, and methods for treating patients
First Claim
1. A compound comprising:
- bismuth anda biologically active agent coordinated to the bismuth;
wherein the biologically active agent comprises at least one heteroatom configured for coordination with the bismuth;
wherein the biologically active agent is levodopa and wherein the compound is selected from Bi(O)(levodopa) and Bi(O)(levodopa)3.
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Accused Products
Abstract
Bismuth-containing compounds include bismuth and a biologically active agent coordinated to the bismuth. The biologically active agent includes at least one heteroatom configured for coordination with the bismuth. Coordination polymers include a polymer matrix that contains a bismuth-containing compound. Methods for modulating a pharmacokinetic property of a biologically active agent include coordinating the biologically active agent to bismuth to form a bismuth-containing compound, and administering the bismuth-containing compound orally to a patient. Methods for treating Parkinson'"'"'s disease, methods for treating hypothyroidism, methods for treating ulcerative colitis, and methods for treating cancer each include administering a bismuth-containing compound to a patient.
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Citations
16 Claims
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1. A compound comprising:
- bismuth and
a biologically active agent coordinated to the bismuth; wherein the biologically active agent comprises at least one heteroatom configured for coordination with the bismuth; wherein the biologically active agent is levodopa and wherein the compound is selected from Bi(O)(levodopa) and Bi(O)(levodopa)3. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
- bismuth and
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15. A method of manufacturing a bismuth-containing compound comprising levodopa, carbidopa and combinations thereof comprising:
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a) providing a solvent comprising water to a reaction chamber; b) adding an amount of levodopa or carbidopa or a mixture thereof to the reaction chamber; c) adding an amount of a source of bismuth to the reaction chamber; and d) isolating the compound as a solid precipitant. - View Dependent Claims (16)
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Specification