Rapid small volume detection of blood ammonia
First Claim
1. A device for measuring an ammonia level in a blood sample, the device comprising:
- a blood sample containment member comprising a substrate for holding the blood sample;
an alkaline substance disposed on the substrate;
an ammonia gas sensor coupled with the blood sample containment member; and
a current measurement member coupled with the ammonia gas sensor,wherein the blood sample containment member comprises a compartment for holding the blood sample,wherein the compartment forms a sealed chamber when the blood sample containment member is coupled with the ammonia gas sensor, andwherein the sealed chamber encloses an anode end of the ammonia gas sensor and the blood sample.
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Abstract
A method for measuring ammonia in a blood sample may involve positioning the blood sample in proximity with an ammonia gas sensor, generating a current with the ammonia gas sensor in response to ammonia gas released from the blood sample, and measuring the current generated by the ammonia gas sensor, using a current measurement member coupled with the ammonia gas sensor. A device for measuring an ammonia level in a blood sample may include a blood sample containment member, an ammonia gas sensor coupled with the blood sample containment member, and a current measurement member coupled with the ammonia gas sensor. The method and device may be used to measure an ammonia level in a blood sample as small as one drop of blood, or approximately 0.05 mL of blood.
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Citations
17 Claims
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1. A device for measuring an ammonia level in a blood sample, the device comprising:
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a blood sample containment member comprising a substrate for holding the blood sample; an alkaline substance disposed on the substrate; an ammonia gas sensor coupled with the blood sample containment member; and a current measurement member coupled with the ammonia gas sensor, wherein the blood sample containment member comprises a compartment for holding the blood sample, wherein the compartment forms a sealed chamber when the blood sample containment member is coupled with the ammonia gas sensor, and wherein the sealed chamber encloses an anode end of the ammonia gas sensor and the blood sample. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification