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Method and system for image processing and patient-specific modeling of blood flow

  • US 10,154,883 B2
  • Filed: 04/06/2016
  • Issued: 12/18/2018
  • Est. Priority Date: 08/12/2010
  • Status: Active Grant
First Claim
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1. A method for simulating perfusion of the myocardial muscle using computed tomography or computed tomographic angiography, the method comprising:

  • receiving imaging data of at least a portion of a patient'"'"'s myocardial muscle and one or more coronary blood vessels of the patient'"'"'s heart;

    identifying, from the imaging data, different three-dimensional regions of the portion of the patient'"'"'s myocardial muscle, wherein each three-dimensional region is identified based on a location of an outflow boundary of one of the one or more coronary blood vessels or a branch extending from the one or more coronary blood vessels;

    generating a three-dimensional model of the portion of the patient'"'"'s myocardial muscle and coronary blood vessels, using the identified three-dimensional regions from the received imaging data;

    simulating blood flow through the three-dimensional model and determining, from the simulating, the blood flow into the different three-dimensional regions of the myocardial muscle into which different branches of the coronary blood vessels lead;

    simulating local perfusion of the myocardial muscle for the different three-dimensional regions of the myocardial muscle from the determined blood flow into the different three-dimensional regions of the myocardial muscle;

    determining one or more three-dimensional regions of the myocardial muscle that are at risk of insufficient perfusion using the simulated local perfusion of the different three-dimensional regions of the myocardial muscle; and

    displaying a map of perfusion on the three-dimensional model of the myocardial muscle, based on the simulated local perfusion of the myocardial muscle for the different three-dimensional regions of the myocardial muscle, wherein the map of perfusion displays one or more of the three-dimensional regions, and identifies the one or more three-dimensional regions that are at risk of insufficient perfusion.

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