Method and system for image processing and patient-specific modeling of blood flow
First Claim
1. A method for simulating perfusion of the myocardial muscle using computed tomography or computed tomographic angiography, the method comprising:
- receiving imaging data of at least a portion of a patient'"'"'s myocardial muscle and one or more coronary blood vessels of the patient'"'"'s heart;
identifying, from the imaging data, different three-dimensional regions of the portion of the patient'"'"'s myocardial muscle, wherein each three-dimensional region is identified based on a location of an outflow boundary of one of the one or more coronary blood vessels or a branch extending from the one or more coronary blood vessels;
generating a three-dimensional model of the portion of the patient'"'"'s myocardial muscle and coronary blood vessels, using the identified three-dimensional regions from the received imaging data;
simulating blood flow through the three-dimensional model and determining, from the simulating, the blood flow into the different three-dimensional regions of the myocardial muscle into which different branches of the coronary blood vessels lead;
simulating local perfusion of the myocardial muscle for the different three-dimensional regions of the myocardial muscle from the determined blood flow into the different three-dimensional regions of the myocardial muscle;
determining one or more three-dimensional regions of the myocardial muscle that are at risk of insufficient perfusion using the simulated local perfusion of the different three-dimensional regions of the myocardial muscle; and
displaying a map of perfusion on the three-dimensional model of the myocardial muscle, based on the simulated local perfusion of the myocardial muscle for the different three-dimensional regions of the myocardial muscle, wherein the map of perfusion displays one or more of the three-dimensional regions, and identifies the one or more three-dimensional regions that are at risk of insufficient perfusion.
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Accused Products
Abstract
Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient'"'"'s heart, and create a three-dimensional model representing at least a portion of the patient'"'"'s heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient'"'"'s heart and determine a fractional flow reserve within the patient'"'"'s heart based on the three-dimensional model and the physics-based model.
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Citations
19 Claims
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1. A method for simulating perfusion of the myocardial muscle using computed tomography or computed tomographic angiography, the method comprising:
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receiving imaging data of at least a portion of a patient'"'"'s myocardial muscle and one or more coronary blood vessels of the patient'"'"'s heart; identifying, from the imaging data, different three-dimensional regions of the portion of the patient'"'"'s myocardial muscle, wherein each three-dimensional region is identified based on a location of an outflow boundary of one of the one or more coronary blood vessels or a branch extending from the one or more coronary blood vessels; generating a three-dimensional model of the portion of the patient'"'"'s myocardial muscle and coronary blood vessels, using the identified three-dimensional regions from the received imaging data; simulating blood flow through the three-dimensional model and determining, from the simulating, the blood flow into the different three-dimensional regions of the myocardial muscle into which different branches of the coronary blood vessels lead; simulating local perfusion of the myocardial muscle for the different three-dimensional regions of the myocardial muscle from the determined blood flow into the different three-dimensional regions of the myocardial muscle; determining one or more three-dimensional regions of the myocardial muscle that are at risk of insufficient perfusion using the simulated local perfusion of the different three-dimensional regions of the myocardial muscle; and displaying a map of perfusion on the three-dimensional model of the myocardial muscle, based on the simulated local perfusion of the myocardial muscle for the different three-dimensional regions of the myocardial muscle, wherein the map of perfusion displays one or more of the three-dimensional regions, and identifies the one or more three-dimensional regions that are at risk of insufficient perfusion. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A non-transitory computer readable medium storing computer program instructions, which when operated on a processor, cause the processor to perform operations comprising:
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receiving imaging data of at least a portion of a patient'"'"'s myocardial muscle and one or more coronary blood vessels of the patient'"'"'s heart; identifying, from the imaging data, different three-dimensional regions of the portion of the patient'"'"'s myocardial muscle, wherein each three-dimensional region is identified based on a location of an outflow boundary of one of the one or more coronary blood vessels or a branch extending from the one or more coronary blood vessels; generating a three-dimensional model of the portion of the patient'"'"'s myocardial muscle and coronary blood vessels, using the identified three-dimensional regions from the received imaging data; simulating blood flow through the three-dimensional model and determining, from the simulating, the blood flow into the different three-dimensional regions of the myocardial muscle into which different branches of the coronary blood vessels lead; simulating local perfusion of the myocardial muscle for the different three-dimensional regions of the myocardial muscle from the determined blood flow into the different three-dimensional regions of the myocardial muscle; determining one or more three-dimensional regions of the myocardial muscle that are at risk of insufficient perfusion using the simulated local perfusion of the different three-dimensional regions of the myocardial muscle; and displaying a map of perfusion on the three-dimensional model of the myocardial muscle, based on the simulated local perfusion of the myocardial muscle for the different three-dimensional regions of the myocardial muscle, wherein the map of perfusion displays one or more of the three-dimensional regions, and identifies the one or more three-dimensional regions that are at risk of insufficient perfusion. - View Dependent Claims (8, 9, 10, 11, 12)
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13. A system for simulating perfusion of the myocardial muscle with the aid of non-dynamic computed tomography or computed tomographic angiography, comprising:
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a data storage device storing instructions for simulating perfusion of the myocardial muscle with the aid of non-dynamic computed tomographic angiography; and a processor configured to execute the instructions to perform a method including; receiving imaging data of at least a portion of a patient'"'"'s myocardial muscle and one or more coronary blood vessels of the patient'"'"'s heart; identifying, from the imaging data, different three-dimensional regions of the portion of the patient'"'"'s myocardial muscle, wherein each three-dimensional region is identified based on a location of an outflow boundary of one of the one or more coronary blood vessels or a branch extending from the one or more coronary blood vessels; generating a three-dimensional model of the portion of the patient'"'"'s myocardial muscle and coronary blood vessels, using the identified three-dimensional regions from the received imaging data; simulating blood flow through the three-dimensional model and determining, from the simulating, the blood flow into the different three-dimensional regions of the myocardial muscle into which different branches of the coronary blood vessels lead; simulating local perfusion of the myocardial muscle for the different three-dimensional regions of the myocardial muscle from the determined blood flow into the different three-dimensional regions of the myocardial muscle; determining one or more three-dimensional regions of the myocardial muscle that are at risk of insufficient perfusion using the simulated local perfusion of the different three-dimensional regions of the myocardial muscle; and displaying a map of perfusion on the three-dimensional model of the myocardial muscle, based on the simulated local perfusion of the myocardial muscle for the different three-dimensional regions of the myocardial muscle, wherein the map of perfusion displays one or more of the identified three-dimensional regions, and identifies the one or more three-dimensional regions that are at risk of insufficient perfusion. - View Dependent Claims (14, 15, 16, 17, 18, 19)
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Specification