Tri-color dual glucose and oxygen sensors and methods of preparing and using them
First Claim
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1. An optical fluorescence sensor comprising:
- a probe for sensing glucose, an intra-reference probe and a matrix, whereinthe probe for sensing glucose is prepared from a compound having formula I;
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Abstract
The present disclosure relates to an optical fluorescence sensor comprising a probe for sensing glucose, an intra-reference probe, and a matrix. The present disclosure also relates to an optical fluorescence dual sensor comprising a probe for sensing glucose having two boronic acid moieties, a probe for sensing oxygen comprising modified porphyrin, an intra-reference probe that is rhodamine-based, and a matrix. The present disclosure additionally relates to methods of preparing these sensors and methods of using them.
10 Citations
25 Claims
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1. An optical fluorescence sensor comprising:
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a probe for sensing glucose, an intra-reference probe and a matrix, wherein the probe for sensing glucose is prepared from a compound having formula I; - View Dependent Claims (2, 3, 18, 19, 20, 21, 22, 23)
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4. An optical fluorescence dual sensor comprising:
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a probe for sensing glucose, a probe for sensing oxygen, an intra-reference probe and a matrix, wherein the probe for sensing glucose is prepared from a compound having formula I; - View Dependent Claims (5, 6, 7, 24, 25)
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8. A method of preparing an optical fluorescence sensor comprising the steps of:
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(a) copolymerizing an intra-reference probe, with 2-hydroxyethyl methacrylate, N-(6-aminohexyl) methacrylamide, and acrylamide onto a modified substrate; and (b) attaching or immobilizing a probe for sensing glucose onto the substrate; wherein the probe for sensing glucose has formula I; - View Dependent Claims (9, 11)
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10. A method of preparing an optical fluorescence sensor comprising the step of:
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copolymerizing a probe for sensing glucose and an intra-reference probe, with 2-hydroxyethyl methacrylate, N-(6-aminohexyl) methacrylamide, and acrylamide onto a modified substrate; wherein the probe for sensing glucose has formula I; - View Dependent Claims (17)
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12. A method of preparing an optical fluorescence dual sensor comprising the steps of:
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(a) copolymerizing a probe for sensing oxygen and an intra-reference probe, with poly(2-hydroxyethyl methacrylate), polyacrylamide, and poly(2-hydroxyethyl methacrylate)-co-polyacrylamide onto a modified substrate; and (b) attaching or immobilizing a probe for sensing glucose onto the substrate; wherein the probe for sensing glucose has formula I; - View Dependent Claims (15, 16)
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13. A method of preparing an optical fluorescence dual sensor comprising the step of:
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copolymerizing a probe for sensing glucose, a probe for sensing oxygen and an intra-reference probe, with 2-hydroxyethyl methacrylate, N-(6-aminohexyl) methacrylamide, and acrylamide onto a modified substrate; wherein the probe for sensing glucose has formula I; - View Dependent Claims (14)
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Specification