Fluorescent detector systems for the detection of chemical perturbations in sterile storage devices
First Claim
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1. A method for monitoring a parameter of one or more samples positioned in an incubator, comprising:
- (a) irradiating a fluorescent species having a first emission intensity at a first emission wavelength and a second emission intensity at a second emission wavelength, wherein the first and second emission wavelengths are not the same, each emission intensity dependent on a parameter, with excitation light emanating from a probe physically isolated from the fluorescent species to provide first and second emission intensities, wherein the fluorescent species is in a sample contained in a vessel in an incubator;
(b) measuring the first and second emission intensities to determine a first parameter reading of the sample; and
(c) repeating step (a) after a pre-determined time and measuring the first and second emission intensities to determine a second parameter reading of the sample.
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Abstract
System and method for detecting and measuring chemical perturbations in a sample. The system and method are useful for non-invasive pH monitoring of blood or blood products sealed in storage bags.
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Citations
12 Claims
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1. A method for monitoring a parameter of one or more samples positioned in an incubator, comprising:
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(a) irradiating a fluorescent species having a first emission intensity at a first emission wavelength and a second emission intensity at a second emission wavelength, wherein the first and second emission wavelengths are not the same, each emission intensity dependent on a parameter, with excitation light emanating from a probe physically isolated from the fluorescent species to provide first and second emission intensities, wherein the fluorescent species is in a sample contained in a vessel in an incubator; (b) measuring the first and second emission intensities to determine a first parameter reading of the sample; and (c) repeating step (a) after a pre-determined time and measuring the first and second emission intensities to determine a second parameter reading of the sample. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method for monitoring the pH of one or more samples positioned in an incubator, comprising:
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(a) irradiating a fluorescent species in a sample contained in a vessel with excitation light emanating from a probe physically isolated from the fluorescent species, wherein the excitation light has a wavelength sufficient to effect fluorescent emission from the fluorescent species, wherein the fluorescent species exhibits a first emission intensity at a first emission wavelength and a second emission intensity at a second emission wavelength, the ratio of the first and second emission intensities being dependent on pH, wherein the first and second emission wavelengths are not the same; (b) measuring the first and second emission intensities to determine the first pH of the sample in the incubator; and (c) repeating step (a) after a pre-determined time and measuring the first and second emission intensities to determine the second pH of the sample in the incubator. - View Dependent Claims (10, 11, 12)
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Specification