Systems and methods for optode imaging
First Claim
1. A system, comprising:
- a plurality of optodes configured to be embedded in tissue, wherein each optode is at a respective location, wherein an excitation light causes the optodes to emit emission light, and wherein the optodes are sensitive to at least one analyte such that the emission light emitted by the optodes is indicative of a presence or absence of at least one analyte in the tissue;
one or more light sources, wherein the one or more light sources are configured to illuminate the plurality of optodes with the excitation light;
an optical filter array, wherein the optical filter array includes for each optode in the plurality of optodes a corresponding plurality of optical filters;
a detector array optically coupled to the optical filter array, wherein the detector array includes for each optode in the plurality of optodes a corresponding plurality of detectors configured to detect light received from the optode'"'"'s respective location via the optode'"'"'s corresponding plurality of optical filters; and
a controller comprising at least one processor, wherein the controller is programmed to carry out operations, the operations comprising;
operating the one or more light sources to illuminate the plurality of optodes with excitation light;
operating the detector array to obtain detector information, wherein the detector information includes for each optode a respective optode signal indicative of light that has been emitted from the optode'"'"'s respective location in response to the illumination from the one or more light sources, filtered through the optode'"'"'s corresponding plurality of optical filters, and detected by the optode'"'"'s corresponding plurality of detectors; and
detecting at least one analyte based on the detector information.
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Abstract
Methods and systems disclosed herein may be operable to detect a presence or absence of an analyte in human tissue. An example method includes operating one or more light sources to illuminate a plurality of optodes with excitation light. Each optode is embedded in tissue at a respective location. The excitation light causes the optodes to emit emission light and the optodes are sensitive to at least one analyte such that the emission light emitted by the optodes is indicative of a presence or absence of at least one analyte in the tissue. An optical filter arrangement includes for each optode in the plurality of optodes a corresponding set of one or more optical filters. The method includes obtaining detector information from a detector arrangement optically coupled to the optical filter arrangement, and detecting the at least one analyte based on the detector information.
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Citations
21 Claims
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1. A system, comprising:
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a plurality of optodes configured to be embedded in tissue, wherein each optode is at a respective location, wherein an excitation light causes the optodes to emit emission light, and wherein the optodes are sensitive to at least one analyte such that the emission light emitted by the optodes is indicative of a presence or absence of at least one analyte in the tissue; one or more light sources, wherein the one or more light sources are configured to illuminate the plurality of optodes with the excitation light; an optical filter array, wherein the optical filter array includes for each optode in the plurality of optodes a corresponding plurality of optical filters; a detector array optically coupled to the optical filter array, wherein the detector array includes for each optode in the plurality of optodes a corresponding plurality of detectors configured to detect light received from the optode'"'"'s respective location via the optode'"'"'s corresponding plurality of optical filters; and a controller comprising at least one processor, wherein the controller is programmed to carry out operations, the operations comprising; operating the one or more light sources to illuminate the plurality of optodes with excitation light; operating the detector array to obtain detector information, wherein the detector information includes for each optode a respective optode signal indicative of light that has been emitted from the optode'"'"'s respective location in response to the illumination from the one or more light sources, filtered through the optode'"'"'s corresponding plurality of optical filters, and detected by the optode'"'"'s corresponding plurality of detectors; and detecting at least one analyte based on the detector information. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method comprising:
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operating a plurality of optodes embedded in tissue, wherein each optode is at a respective location, wherein an excitation light causes the optodes to emit emission light, wherein the optodes are sensitive to at least one analyte such that the emission light emitted by the optodes is indicative of a presence or absence of at least one analyte in the tissue; operating one or more light sources to illuminate the plurality of optodes with the excitation light, wherein an optical filter array includes for each optode in the plurality of optodes a corresponding plurality of optical filters; operating a detector array to obtain detector information, wherein the detector array is optically coupled to the optical filter array, wherein the detector array includes for each optode in the plurality of optodes a corresponding plurality of detectors operable to detect light received from the optode'"'"'s respective location via the optode'"'"'s corresponding plurality of optical filters, wherein the detector information includes for each optode a respective optode signal indicative of light that has been emitted from the optode'"'"'s respective location in response to the illumination from the one or more light sources, filtered through the optode'"'"'s corresponding plurality of optical filters, and detected by the optode'"'"'s corresponding plurality of detectors; and detecting at least one analyte based on the detector information. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21)
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Specification