Multi-layer biodegradable device having adjustable drug release profile
First Claim
1. A method for applying a device in a sinus of a patient, the method comprising:
- advancing the device comprising a first film-layer and a second film-layer to the sinus, the first film-layer comprising fibrinogen and a first therapeutic agent, the second film-layer comprising fibrinogen and a second therapeutic agent;
applying the device on sinus tissue in the sinus;
releasing the first therapeutic agent into the sinus tissue from the first film-layer at a first release profile; and
releasing the second therapeutic agent into the sinus tissue from the second film-layer at a second release profile different from the first release profile; and
wherein the first film-layer is formed by processing a first composition comprising the fibrinogen, the first therapeutic agent, and a first amount of non-aqueous solvent and the second film-layer is formed by processing a second composition comprising the fibrinogen, the second therapeutic agent, and a second amount of non-aqueous solvent different from the first amount of non-aqueous solvent.
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Accused Products
Abstract
Methods and apparatus for a biodegradable multi-layer device suitable for medical applications are provided, wherein the device is formed from multiple film-layers configured to have different characteristics from one another such as different release profiles for therapeutic agents, adhesive properties, stiffness properties, and solubility properties. The film-layers may include a solid fibrinogen component. A device having multiple film-layers may take a non-adherent form during delivery to a target location within or on tissue, and thereafter may be exposed to moisture to take an adherent form on the tissue. The device may include a number of additives, including materials to improve the mechanical properties of the device, or one or more therapeutic or contrast agents.
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Citations
19 Claims
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1. A method for applying a device in a sinus of a patient, the method comprising:
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advancing the device comprising a first film-layer and a second film-layer to the sinus, the first film-layer comprising fibrinogen and a first therapeutic agent, the second film-layer comprising fibrinogen and a second therapeutic agent; applying the device on sinus tissue in the sinus; releasing the first therapeutic agent into the sinus tissue from the first film-layer at a first release profile; and releasing the second therapeutic agent into the sinus tissue from the second film-layer at a second release profile different from the first release profile; and wherein the first film-layer is formed by processing a first composition comprising the fibrinogen, the first therapeutic agent, and a first amount of non-aqueous solvent and the second film-layer is formed by processing a second composition comprising the fibrinogen, the second therapeutic agent, and a second amount of non-aqueous solvent different from the first amount of non-aqueous solvent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification