Flow control in microfluidic systems
First Claim
Patent Images
1. A device comprising:
- a microfluidic system comprising;
a first plug comprising a first fluid and a second plug comprising a second fluid contained in the microfluidic system, wherein the first and second plugs are separated by a separation fluid;
an inlet and an outlet;
an analysis region positioned between the inlet and the outlet;
a microfluidic channel in fluid communication with the analysis region, the microfluidic channel comprising a first channel portion having a first cross-sectional area; and
a flow constriction region positioned downstream of the first channel portion and upstream of the outlet, wherein the flow constriction region has a second cross-sectional area, the second cross-sectional area being at least 10 times smaller than the first cross-sectional area, wherein the flow constriction region has a height and/or a width of less than 75 microns.
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Abstract
Microfluidic systems and methods including those that provide control of fluid flow are provided. Such systems and methods can be used, for example, to control pressure-driven flow based on the influence of channel geometry and the viscosity of one or more fluids inside the system.
117 Citations
22 Claims
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1. A device comprising:
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a microfluidic system comprising; a first plug comprising a first fluid and a second plug comprising a second fluid contained in the microfluidic system, wherein the first and second plugs are separated by a separation fluid; an inlet and an outlet; an analysis region positioned between the inlet and the outlet; a microfluidic channel in fluid communication with the analysis region, the microfluidic channel comprising a first channel portion having a first cross-sectional area; and a flow constriction region positioned downstream of the first channel portion and upstream of the outlet, wherein the flow constriction region has a second cross-sectional area, the second cross-sectional area being at least 10 times smaller than the first cross-sectional area, wherein the flow constriction region has a height and/or a width of less than 75 microns. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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2. A method, comprising:
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in a microfluidic system comprising; a first plug comprising a first fluid and a second plug comprising a second fluid contained in the microfluidic system, wherein the first and second plugs are separated by a separation fluid; an inlet and an outlet; an analysis region positioned between the inlet and the outlet; a microfluidic channel in fluid communication with the analysis region, the microfluidic channel comprising a first channel portion having a first cross-sectional area; and a flow constriction region positioned downstream of the first channel portion and upstream of the outlet, wherein the flow constriction region has a second cross-sectional area, the second cross-sectional area being at least 10 times smaller than the first cross-sectional area, wherein the flow constriction region has a height and/or a width of less than 75 microns, performing the steps of; flowing the first plug at a first flow rate; flowing the first plug from the first channel portion to the second channel portion; and causing a volumetric flow rate of the first plug to decrease by a factor of at least 50 in the microfluidic system.
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Specification