Variant forms of urate oxidase and use thereof
First Claim
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1. A method of reducing a uric acid level in a subject in need thereof, comprising administering a pharmaceutical composition comprising a conjugate comprising a uricase and polyethylene glycol (PEG), wherein the uricase comprises the amino acid sequence of SEQ ID NO:
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Abstract
Genetically modified proteins with uricolytic activity are described. Proteins comprising truncated urate oxidases and methods for producing them, including PEGylated proteins comprising truncated urate oxidase are described.
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23 Claims
- 1. A method of reducing a uric acid level in a subject in need thereof, comprising administering a pharmaceutical composition comprising a conjugate comprising a uricase and polyethylene glycol (PEG), wherein the uricase comprises the amino acid sequence of SEQ ID NO:
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