Reagent preparing device, reagent preparing method, and specimen processing system

• US 10,161,950 B2
• Filed: 03/29/2010
• Issued: 12/25/2018
• Est. Priority Date: 03/31/2009
• Status: Active Grant

• Current Assignee: Sysmex Corporation
• Original Assignee: Sysmex Corporation
• Inventors: Okubo, Koichi, Nakanishi, Noriyuki, Oguro, Masahiko, Asahara, Tomoyuki, Nakajima, Takayuki
• Primary Examiner(s): Whatley, Benjamin R
• Application Number:
  US12/748,768
• Publication Number:
  US 20100248208A1
• Time in Patent Office: 3,193 Days
• CPC Class Codes: G01N 35/00663 of consumables
• CPC Class Codes: G01N 35/1002 Reagent dispensers

Abstract

A reagent preparing device capable of supplying a predetermined reagent, which includes a first liquid and a second liquid different from the first liquid, to a measurement section for measuring a specimen using the reagent, comprising: a pressure generator for generating pressure to transfer liquid; a reagent preparing section for executing a preparation operation of the predetermined reagent using the pressure generated by the pressure generator; and a controller configured for performing operations comprising: determining whether or not the reagent preparing section is executing the preparation operation, and controlling the generation of the pressure by the pressure generator according to the determination result, is disclosed. A reagent preparing method and a specimen processing system are also disclosed.

Claims

1. A reagent preparing device capable of supplying a reagent, which includes a first liquid and a second liquid different from the first liquid, to a plurality of measurement apparatuses for measuring a specimen using the reagent, comprising:

a pressure generator with a pressure generation mechanism which generates pressure to transfer liquid, and a switch device which switches to whether or not to supply current to a motor;

a plurality of reagent preparing apparatuses, each respective reagent preparing apparatus is connected to the pressure generator to execute a preparation operation of the reagent using the pressure generated by the pressure generator, wherein each respective reagent preparing apparatus includes;

a first vessel which accommodates the first liquid, which includes a first chamber and a first switch coupled to the first chamber and positioned for detecting whether or not a predetermined amount of the first liquid is accommodated in the first chamber;

a second vessel which accommodates the second liquid, which includes a second chamber and a second switch coupled to the second chamber and positioned for detecting whether or not a predetermined amount of the second liquid is accommodated in the second chamber,

a stirring chamber, connected to the first vessel and the second vessel through a flow path, configured to prepare the reagent using the first liquid and the second liquid, wherein the pressure generator is connected to the first-vessel, the second vessel and the stirring chamber;

a supply chamber, connected to the stirring chamber, the supply chamber accommodates the reagent, and a third switch coupled to the supply chamber and positioned to detect whether or not a predetermined amount of the reagent is accommodated in the supply chamber; and

a processor programmed to control the pressure generator to;

stop generation of the pressure by controlling the switching operation of the switch device in response to;

(i) a detection result that the first switch detects the predetermined amount of the first liquid in the first chamber for each and every one of the plurality of reagent preparing apparatuses,

(ii) a detection result that the second switch detects the predetermined amount of the second liquid in the second chamber for each and every one of the plurality of reagent preparing apparatuses, and

(iii) a detection result that the third switch detects the predetermined amount of the predetermined reagent in the supply chamber for each and every one of the plurality of reagent preparing apparatuses; and

continue generation of the pressure by controlling the switching operation of the switch device in response to at least one of;

(iv) a detection result that the first switch detects the predetermined amount of the first liquid is not in the first chamber for at least one of the plurality of reagent preparing apparatuses,

(v) a detection result that the second switch detects the predetermined amount of the second liquid is not in the second chamber for at least one of the plurality of reagent preparing apparatuses, and

(vi) a detection result that the third switch detects the predetermined amount of the predetermined reagent is not in the supply chamber for at least one of the plurality of reagent preparing apparatuses.

2. The reagent preparing device according to claim 1, wherein the processor is programmed to cause a determination that when transfer of liquid for preparing the reagent has been completed and to control the pressure generator to stop the generation of the pressure in response to a determination that transfer of liquid for preparing the reagent has been completed.

3. The reagent preparing device according to claim 2, wherein the processor is programmed to cause a determination that when transfer of the first liquid, the second liquid, and a mixed solution of the first liquid and the second liquid has been completed and to control the pressure generator to stop the generation of the pressure in response to a determination that transfer of the first liquid, the second liquid, and a mixed solution of the first liquid and the second liquid has been completed.

4. The reagent preparing device according to claim 1, wherein the processor is programmed to cause the pressure generator to control starting the generation of the pressure by starting a supply of the current to the motor in response to:

(i) a detection result that the third switch detects the predetermined amount of the reagent is not in the supply chamber after the pressure generated by the pressure generator is stopped.

5. The reagent preparing device according to claim 4, wherein each respective reagent preparing apparatus further comprises a pressure sensor for detecting the magnitude of pressure generated by the pressure generator;

and

the processor is programmed to resume the preparation operation by the respective reagent preparing apparatus in response to a detection result that the magnitude of the pressure detected by the pressure sensor reaches a predetermined range.

6. The reagent preparing device according to claim 1, wherein

the pressure generator further comprises a cooling fan connected to the switch device,

the switch unit switches whether or not to supply current to the cooling fan, and

the processor is programmed to stop the operation of the cooling fan by controlling the switching operation of the switch device.

7. A specimen processing system comprising:

a plurality of measurement apparatuses for measuring, each of which is configured to measure a specimen using a reagent which includes a first liquid and a second liquid which is different from the first liquid;

a pressure generator with a pressure generation mechanism which generates pressure to transfer liquid, and a switch device which switches to whether or not to supply current to a motor;

a plurality of reagent preparing apparatuses, each respective reagent preparing apparatus executes a preparation operation of the reagent using the pressure generated by the pressure generator, wherein each of the reagent preparing apparatus includes;

a first vessel which accommodates the first liquid, which includes a first chamber and a first switch coupled to the first chamber and positioned for detecting whether or not a predetermined amount of the first liquid is accommodated in the first chamber;

a second vessel which accommodates the second liquid, which includes a second chamber and a second switch coupled to the second chamber and position for detecting whether or not a predetermined amount of the second liquid is accommodated in the second chamber,

a stirring chamber, connected to the first vessel and the second-vessel through a flow path, configured to prepare the reagent using the first liquid and the second liquid, wherein the pressure generator is connected to the first vessel, the second vessel and the stirring chamber;

a supply chamber, connected to the stirring chamber and the measurement section, wherein the supply chamber includes a third switch coupled to the supply chamber and positioned for detecting whether or not a predetermined amount of the reagent is accommodated in the supply chamber; and

a processor programmed to control the pressure generator to;

stop generation of the pressure by stopping supply of current to the motor in response to;

(i) a detection result that the first switch detects the predetermined amount of the first liquid in the first chamber for each and every one of the plurality of reagent preparing apparatuses,

(ii) a detection result that the second switch detects the predetermined amount of the second liquid in the second chamber for each and every one of the plurality of reagent preparing apparatuses, and

(iii) a detection result that the third switch detects the predetermined amount of the reagent in the supply chamber for each and every one of the plurality of reagent preparing apparatuses; and

continue generation of the pressure by controlling the switching operation of the switch device in response to at least one of;

(iv) a detection result that the first switch detects the predetermined amount of the first liquid is not in the first chamber for at least one of the plurality of reagent preparing apparatuses,

(v) a detection result that the second switch detects the predetermined amount of the second liquid is not in the second chamber for at least one of the plurality of reagent preparing apparatuses, and

(vi) a detection result that the third switch detects the predetermined amount of the predetermined reagent is not in the supply chamber for at least one of the plurality of reagent preparing apparatuses.