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Systems and methods for determining the probability of a pregnancy at a selected point in time

  • US 10,162,800 B2
  • Filed: 10/11/2013
  • Issued: 12/25/2018
  • Est. Priority Date: 10/17/2012
  • Status: Active Grant
First Claim
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1. A system for determining a probability of achieving a pregnancy at a selected point in time, the system comprising:

  • a central processing unit (CPU); and

    storage coupled to said CPU for storing instructions that when executed by the CPU cause the CPU to;

    accept as input, data representative of a plurality of fertility-associated phenotypic traits of a female subject;

    analyze the input data using a prognosis predictor generated by;

    obtaining a reference set of data from a plurality of women across one or more reproductive cycles, the reference set of data comprising fertility-associated phenotypic traits and known pregnancy outcomes, wherein the plurality of women accounts for a dropout population of women who ceased pregnancy attempts prior to reaching a live birth outcome and a non-dropout population of women who continued pregnancy attempts until live birth;

    determining one or more correlations between the at least one of the fertility-associated phenotypic traits and the known pregnancy outcomes at a plurality of time points across the reproductive cycles, wherein the dropout population is accounted for by estimating a likelihood of dropout for each subject at each reproductive cycle and weighing the women in the non-dropout population proportionally to the likelihood of dropout; and

    training the prognosis predictor on the reference set of data;

    provide a probability of achieving a pregnancy for the female subject at a selected point in time as a result of running the prognosis predictor on said input data; and

    treating the female subject with a fertility treatment based on the probability of achieving a pregnancy.

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