Systems and methods for quantifying regional fissure features
First Claim
1. A method for analyzing a patient based on a volumetric pulmonary scan comprising:
- receiving a first volumetric pulmonary scan representative of the patient'"'"'s pulmonary structure;
mapping the first volumetric pulmonary scan to a reference domain;
determining one or more fissure features associated with a plurality of regions in the reference domain and within the first volumetric pulmonary scan;
comparing, in each of the plurality of regions, the determined one or more fissure features to a plurality of fissure atlases, each atlas comprising statistical data associated with the one or more fissure features for a population based on regional analysis of volumetric pulmonary scans of that population;
classifying the patient into one or more of the populations based on the comparison of the determined one or more fissure features.
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Accused Products
Abstract
Analysis of pulmonary scans representative of a patient'"'"'s pulmonary structure can be used to classify a patient into one or more of a plurality of populations. The patient'"'"'s scan can be mapped to a reference domain and analyzed to determine one or more fissure features associated with a plurality of regions in the reference domain. Comparison of the determined fissure features with a plurality of fissure atlases, each associated with different population, can be performed to classify the patient into one or more of the populations. Data from different fissure atlases can be compared to determine regions in the fissure atlases that distinguish one population from another. Such distinguishing regions can improve the ability to classify the patient while reducing errors based on false classifications.
10 Citations
24 Claims
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1. A method for analyzing a patient based on a volumetric pulmonary scan comprising:
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receiving a first volumetric pulmonary scan representative of the patient'"'"'s pulmonary structure; mapping the first volumetric pulmonary scan to a reference domain; determining one or more fissure features associated with a plurality of regions in the reference domain and within the first volumetric pulmonary scan; comparing, in each of the plurality of regions, the determined one or more fissure features to a plurality of fissure atlases, each atlas comprising statistical data associated with the one or more fissure features for a population based on regional analysis of volumetric pulmonary scans of that population; classifying the patient into one or more of the populations based on the comparison of the determined one or more fissure features. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A system for assessing a volumetric pulmonary scan of a patient comprising:
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a database comprising a plurality of fissure atlases, each fissure atlas comprising statistical data regarding one or more fissure features in a plurality of volumetric pulmonary regions for a population; and a processor configured to; statistically analyze the one or more fissure features in the plurality of volumetric pulmonary regions to determine, for each fissure feature, one or more distinguishing regions; receive a first set of volumetric pulmonary scan data representative of the volumetric structure of a patient'"'"'s lungs; determine the one or more fissure features in the first set of volumetric pulmonary scan data at a plurality of regions; compare the determined one or more fissure features to the plurality of fissure atlases in the database; and classify the first set of volumetric pulmonary scan data into one or more of the populations based on the comparison. - View Dependent Claims (12, 13, 14, 15, 16)
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17. A method comprising:
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acquiring a first plurality of three-dimensional pulmonary models, each of the models being representative of the pulmonary structure of a patient belonging to a first population; registering each of the three-dimensional models in the first plurality of three-dimensional models to a reference domain to create a first atlas; statistically analyzing the first plurality of registered three-dimensional models in the first atlas to determine a first fissure feature at each of a plurality of regions in the first atlas; acquiring a second plurality of three-dimensional pulmonary models, each of the models being representative of the pulmonary structure of a patient belonging to a second population, the second population being different from the first; registering each of the three-dimensional models in the second plurality of three-dimensional models to the reference domain to create a second atlas; statistically analyzing the second plurality of registered three-dimensional models in the second atlas to determine the first fissure feature at each of a plurality of regions in the second atlas; for each of a plurality of regions in the first and second atlases, comparing the first fissure feature of the first atlas to the first fissure feature of the second atlas to determine regions in which the first fissure feature differs significantly between the first and second populations and considering such regions to be distinguishing regions associated with the first population, the second population, and the first fissure feature; receiving a diagnostic three-dimensional pulmonary model of a first patient'"'"'s lungs; registering the received diagnostic three-dimensional pulmonary model to the reference domain; analyzing the first fissure feature in the distinguishing regions in the diagnostic three-dimensional pulmonary model; and predicting if the first patient is in the first population or the second population based on the analyzed first fissure feature in the distinguishing regions in the diagnostic three-dimensional pulmonary model. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24)
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Specification