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Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same

  • US 10,166,294 B2
  • Filed: 07/08/2016
  • Issued: 01/01/2019
  • Est. Priority Date: 01/11/2008
  • Status: Active Grant
First Claim
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1. A heterofunctional polyoxazoline derivative of the general structure:


  • R1

    {[N(COX)CH2CH2]o

    [N(COR2)CH2

    CH2)]n

    [N(COY)CH2

    CH2)]m}a

    Zwherein;

    R1 is an initiating group;

    R2 is independently selected for each repeating unit from an unsubstituted or substituted alkyl, an unsubstituted or substituted alkenyl, an unsubstituted or substituted aralkyl or an unsubstituted or substituted heterocyclylalkyl group;

    X is a pendent moiety containing a first functional group;

    Y is a pendent moiety containing a second functional group;

    Z is a terminating nucleophile;

    a is ran which indicates a random copolymer or block which indicates a block copolymer;

    o and m are each an integer independently selected from 1-50;

    n is an integer selected from 0-1000; and

    wherein the first and second functional groups are each independently an alkyne, an amine, an oxyamine, an aldehyde, a ketone, an acetal, a ketal, an ester, a carboxylic acid, an activated carboxylic acid, an active carbonate, a chloroformate, an alcohol, an azide, a vinyl sulfone, a maleimide or orthopyridyl disulfide.

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