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Devices, systems and methods for determining parameters of one or more phases of an injection procedure

  • US 10,166,326 B2
  • Filed: 03/13/2015
  • Issued: 01/01/2019
  • Est. Priority Date: 11/24/2004
  • Status: Active Grant
First Claim
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1. A system for enabling delivery of fluid in an injection procedure to be performed on a patient in connection with a diagnostic imaging procedure, the system comprising:

  • (a) a controller operably associated with at least one pressurizing mechanism though which at least one of a first fluid and a second fluid contained within at least one fluid container is injectable into the patient, the first fluid comprising a contrast enhancing agent and adapted to enhance contrast of images obtained during the diagnostic imaging procedure, the second fluid comprising a non-contrast enhancing fluid;

    (b) the controller including a programming system for programming of an injection protocol comprising a plurality of phases to effect enhancement of at least one region of interest of the patient over a scan duration of the diagnostic imaging procedure, the plurality of phases comprising a first phase in which the first fluid is to be injected and a second phase in which an admixture of the non-contrast enhancing fluid with the first fluid is to be injected;

    (c) a parameter generator inclusive of an algorithm associated with the programming system, the parameter generator for determining parameters of the injection protocol based in part upon a type of the injection procedure to be performed and the algorithm according to which at least a volume of the first phase, Vol1, and a volume of the second phase, Vol2, are determined using;


    Vol1=durationscan×

    Q
    1 and
    Vol2=((tscan_end

    propagation delay)−

    duration1

    Q2 where durationscan is the scan duration, Q1 is a flow rate of the first phase;

    duration1 is a duration of the first phase, propagation delay is a delay in propagation of the contrast enhancing fluid from an injection site to the at least one region of interest, Q2 is a flow rate of the second phase, and tscan-end is computed using;


    tscan-end=ttest-bolus-peak+durationscan where ttest-bolus-peak is a time to peak enhancement that can be obtained from an injection of a test bolus of the contrast enhanced fluid into the patient; and

    (d) the parameter generator is further characterized in that the algorithm enables computation of a ratio of the admixture based on at least a peak enhancement that occurs in the at least one region of interest as a result of the injection of the test bolus.

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