Automatic closed-loop control adjustments and infusion systems incorporating same
First Claim
1. A method of operating an infusion device comprising a motor operable to deliver a fluid to a user, the method comprising:
- identifying a condition of the user that is likely to influence a response to the fluid in a body of the user;
classifying the condition as exercise; and
after classifying the condition as exercise;
estimating an amount of energy expenditure during the exercise;
calculating a change in glycemic level for the user based on the amount of energy expenditure;
determining an equivalent insulin amount based on the change in glycemic level;
determining an adjusted proportional gain coefficient based on a first difference between a daily insulin requirement for the user and the equivalent insulin amount;
determining a delivery command by applying the adjusted proportional gain coefficient to a second difference between a measured glucose value obtained from a glucose sensing arrangement and a target blood glucose; and
operating the motor of the infusion device in accordance with the delivery command to deliver the fluid to the user in accordance with the adjusted proportional gain coefficient.
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Abstract
Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device capable of delivering fluid to a user involves identifying a condition of the user that is likely to influence a response to the fluid in the body of the user and classifying the condition as a first type of a plurality of types of conditions. After classifying the condition as the first type, the method continues by adjusting control information for operating the infusion device based on the first type and operating the infusion device to deliver the fluid to the user in accordance with the adjusted control information.
243 Citations
19 Claims
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1. A method of operating an infusion device comprising a motor operable to deliver a fluid to a user, the method comprising:
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identifying a condition of the user that is likely to influence a response to the fluid in a body of the user; classifying the condition as exercise; and after classifying the condition as exercise; estimating an amount of energy expenditure during the exercise; calculating a change in glycemic level for the user based on the amount of energy expenditure; determining an equivalent insulin amount based on the change in glycemic level; determining an adjusted proportional gain coefficient based on a first difference between a daily insulin requirement for the user and the equivalent insulin amount; determining a delivery command by applying the adjusted proportional gain coefficient to a second difference between a measured glucose value obtained from a glucose sensing arrangement and a target blood glucose; and operating the motor of the infusion device in accordance with the delivery command to deliver the fluid to the user in accordance with the adjusted proportional gain coefficient. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method of operating an infusion device comprising a motor operable to deliver a fluid to a user, the method comprising:
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identifying a condition of the user that is likely to influence a response to the fluid in a body of the user; classifying the condition as stress; and in response to classifying the condition as stress; estimating a change in glycemic level for the user based at least in part on an intensity of the stress; determining an equivalent insulin amount based on the change in glycemic level; and determining an adjusted proportional gain coefficient based on a first difference between a daily insulin requirement for the user and the equivalent insulin amount; and determining a delivery command by applying the adjusted proportional gain coefficient to a second difference between a measured glucose value obtained from a glucose sensing arrangement and a target blood glucose; and operating the motor of the infusion device in accordance with the delivery command. - View Dependent Claims (8, 9)
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10. A method of operating an infusion device capable of delivering insulin to a user, the method comprising:
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obtaining heart rate measurement data for the user using a heart rate sensing arrangement; identifying an insulin sensitivity condition based on the heart rate measurement data when a heart rate associated with the user is greater than a first threshold and a heart rate variability associated with the user is less than a second threshold value; obtaining an activity metric for the user; classifying the insulin sensitivity condition as stress when the activity metric is less than a third threshold value; and after classifying the insulin sensitivity condition as stress; automatically adjusting control information for operating the infusion device to account for an anticipated increase in the user'"'"'s insulin resistance based on the stress, resulting in adjusted control information; determining one or more delivery commands for operating a motor of the infusion device in accordance with the adjusted control information; and operating the motor to deliver the insulin to the user in accordance with the one or more delivery commands. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification