Lead and methods for brain monitoring and modulation

• US 10,166,385 B2
• Filed: 05/02/2014
• Issued: 01/01/2019
• Est. Priority Date: 07/31/2006
• Status: Active Grant

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: Bedenbaugh, Purvis
• Primary Examiner(s): Marlen, Tammie K
• Application Number:
  US14/268,950
• Publication Number:
  US 20140324117A1
• Time in Patent Office: 1,705 Days
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/0536 Preventing neurodegenerative response or inflammatory reaction

Abstract

An apparatus, a system and methods for modulating and monitoring tissue have an elongate member with proximal and distal ends and a plurality of annular stimulating electrodes axially arranged along the elongate member. The stimulating electrodes are disposed near the distal end and are adapted to pass current into tissue. At least one of the annular stimulating electrodes has at least three independent stimulation points on the electrode. The apparatus also includes a plurality of recording electrodes that are adapted to measure local tissue potentials and a plurality of conductors are coupled with the recording and stimulating electrodes. An optional multiple contact connecting terminal may be coupled with the conductors and is disposed near the proximal end of the elongate member.

Claims

1. An electrical stimulation lead, comprising:

an elongate body having a circumference, a proximal portion, a distal portion, and a distal tip;

a first multiple contact connecting terminal disposed along the proximal portion of the elongate body and comprising a plurality of first electrical contacts;

a second multiple contact connecting terminal, separated from the first multiple contact connecting terminal, disposed along the proximal portion of the elongate body and comprising a plurality of second electrical contacts;

at least two stimulating regions longitudinally spaced-apart from each other and disposed along the distal portion of the elongate body, each stimulating region comprising at least three independent stimulation electrodes arranged around the circumference of the elongate body and first insulating material disposed between the stimulation electrodes;

a ring electrode longitudinally spaced-apart and proximal to at least two of the at least two stimulating regions, wherein the ring electrode is a single electrode forming an unbroken ring around the electrical stimulation lead;

and

a plurality of conductors extending along the elongate body to electrically couple the first and second electrical contacts of the first and second multiple contact connecting terminals with the stimulation electrodes and the ring electrode, wherein each of the stimulation electrodes and the ring electrode is attached to a different one of the conductors and each of the conductors is attached to a different one of the first and second electrical contacts of the first and second multiple contact connecting terminals.

2. The electrical stimulation lead of claim 1, wherein the at least two stimulating regions is exactly two stimulating regions and each stimulating region has exactly three independent stimulation electrodes.

3. The electrical stimulation lead of claim 1, wherein the ring electrode is disposed proximal to all of the at least two simulating regions.

4. The electrical stimulation lead of claim 1, wherein each stimulating region has exactly three independent stimulation electrodes.

5. The electrical stimulation lead of claim 1, wherein the stimulation electrodes of each of the at least two stimulating regions form a broken ring around the lead.

6. The electrical stimulation lead of claim 1, further comprising a distal stimulating electrode disposed at the distal tip of the elongate body and second insulating material extending distally from the at least two stimulating regions and separating the distal stimulating electrode from the at least two stimulating regions.

7. The electrical stimulation lead of claim 1, wherein the elongate body defines a central lumen.

8. The electrical stimulation lead of claim 7, wherein the conductors are all arranged in one or two concentric rings around the central lumen.

9. The electrical stimulation lead of claim 1, wherein at least one of the at least two stimulating regions has exactly three independent stimulation electrodes.

10. A method of stimulating tissue, the method comprising:

implanting the electrical stimulation lead of claim 1 in patient tissue; and

delivering current through at least one of the stimulation electrodes, but less than all of the stimulation electrodes, of one of the at least two stimulating regions to steer the current towards a selected portion of the patient tissue.

11. The method of claim 10, wherein delivering current comprises steering the current through the patient tissue by independently changing which of the stimulation electrodes delivers current.

12. The method of claim 10, wherein the patient tissue is brain tissue.