Focused ultrasound guiding system and method thereof

• US 10,166,410 B2
• Filed: 02/27/2013
• Issued: 01/01/2019
• Est. Priority Date: 06/08/2012
• Status: Active Grant

• Current Assignee: Chang GUNG University
• Original Assignee: Chang GUNG University
• Inventors: Liu, Hao-Li, Tsai, Hong-Chieh, Lu, Yu-Jen, Wei, Kuo-Chen
• Primary Examiner(s): Cattungal, Sanjay
• Application Number:
  US13/779,134
• Publication Number:
  US 20130331685A1
• Time in Patent Office: 2,134 Days
• CPC Class Codes: A61B 2017/00725 Calibration or performance testing
• CPC Class Codes: A61B 2090/374 NMR or MRI
• CPC Class Codes: A61B 2090/3762 using computed tomography systems [CT]
• CPC Class Codes: A61B 5/0042 for the brain
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 6/032 Transmission computed tomography [CT]
• CPC Class Codes: A61B 6/501 for diagnosis of the head, e.g. neuroimaging or craniography
• CPC Class Codes: A61B 8/0808 for diagnosis of the brain
• CPC Class Codes: A61B 90/11 with guides for needles or instruments, e.g. arcuate slides or ball joints
• CPC Class Codes: A61B 90/50 Supports for surgical instruments, e.g. articulated arms
• CPC Class Codes: A61N 2007/0021 Neural system treatment
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00
• CPC Class Codes: F04C 2270/041 Controlled or regulated

Abstract

The present invention discloses a neuronavigation-guided focused ultrasound system and a method for the same, which are used to guide focused ultrasound energy to a target point. The system of the present invention comprises a focused ultrasound device, a neuronavigation system and a fixture. According to an image of an interested region of an individual, a focus point of the focused ultrasound device, and tracking points provided by the neuronavigation system, the neuronavigation system performs a calibration process and establishes a positional relationship between the focus point and the image of the interested region. Thereby, the neuronavigation system can recognize the focus point and guide focused ultrasound to the target point.

Claims

1. An ultrasound system, which guides a focused ultrasound energy to a target point located in a tissue of a central nervous system, comprising:

a focused ultrasound device generating a focus point and delivering said energy to said target point which is a tissue wrapped by a hard tissue, and said target point is located in an interested region of an individual;

a first tracking point, a second tracking point and a computer unit, wherein said first tracking point provides fixed reference coordinates and is arranged at a location whose relative position to said interested region of said individual is invariable, and wherein said second tracking point is arranged on an ultrasonic transducer of said focused ultrasound device, and said computer unit retrieves an image of said interested region of said individual, and said image of said interested region of said individual is a previously obtained image obtained with an MRI (Magnetic Resonance Imaging) technology or a CT (Computed Tomography) technology;

reference points on said interested region with spatial positions, and wherein said computer unit records said reference points on said interested region to determine coordinates of said reference points in said image of said interested region;

a calibration tracker connecting with said computer unit;

a dummy arranged on said ultrasonic transducer, wherein said dummy includes a tip pointing out a spatial position of said focus point, and said tip of said dummy, said second tracking point and said first tracking point are tracked by said calibration tracker and said computer unit to search said spatial position of said, focus point and said computer unit compares said spatial positions of said first tracking point, said second tracking point and said reference points with said coordinates of said first tracking point, said second tracking point and said reference points in said image of said interested region to establish the positional relationship between said first tracking point, said second tracking point and said reference points in said image of said interested region, whereby said spatial position of said focus point corresponds to coordinates of said focus point in said image of said interested region based on known positional relationship between said second tracking point and said focus point; and

a fixture fixing said interested region of said individual.

2. The ultrasound system according to claim 1, wherein said focused ultrasound device further comprises

a signal generator generating an ultrasonic signal;

and

a signal amplifier electrically connecting with said signal generator, electrically connecting with said ultrasonic transducer and amplifying said ultrasonic signal into said focused ultrasound; and

said ultrasonic transducer delivers said focused ultrasound to said target point, wherein a central frequency of said focused ultrasound resonates with said ultrasonic transducer.

3. The ultrasound system according to claim 2, wherein said focused ultrasound device further includes a power meter electrically connecting with said ultrasonic transducer and measuring power of said focused ultrasound.

4. The ultrasound system according to claim 2, wherein said ultrasonic signal is a sinusoidal signal.

5. The ultrasound system according to claim 1, wherein said fixture comprises a sliding track and a fixed track, and wherein an ultrasonic transducer of said focused ultrasound device is arranged on said sliding track.

6. The ultrasound system according to claim 5, wherein said fixture further comprises a fixing device, and wherein said fixing device is worn by said individual and fixes said interested region of said individual in retrieving said image of said interested region of said individual.

7. The ultrasound system according to claim 6, wherein said fixing device is a thermoplastic mold.

8. The ultrasound system according to claim 1, wherein said fixture comprises a sliding track and a fixed track, and wherein said first tracking point is arranged on said fixed track, and wherein said second tracking point is arranged on said sliding track.

9. The ultrasound system according to claim 1, wherein said focused ultrasound is applied to cauterization, stimulating local or deep-seated cells, regulating local or deep-seated cells, enhancing blood vessel permeability, dissolving thrombi, and locally delivering medicine.

10. The ultrasound system according to claim 1, wherein said focused ultrasound is applied to enhance blood-to-brain permeability.

11. The ultrasound system according to claim 1, wherein said focused ultrasound device is a multi-point focused ultrasound device.

12. A focused ultrasound energy delivery method for delivering an energy, which guides a focused ultrasound energy to a target point located in a tissue of a central nervous system, comprising steps of:

providing a ultrasound system comprising a focused ultrasound device, a fixture, a dummy and a calibration tracker, wherein said ultrasound system further includes a first tracking point, a second tracking point and a computer unit, and wherein said first tracking point provides fixed reference coordinates and is arranged at a location whose relative position to an interested region of an individual is invariable, and wherein said second tracking point is arranged on an ultrasonic transducer of said focused ultrasound device, and wherein said dummy is arranged on said ultrasonic transducer, wherein said dummy includes a tip pointing out a spatial position of said focus point, and wherein said calibration tracker connects with said computer unit, wherein said focused ultrasound device generates said energy, and wherein said ultrasound system guides said energy to said target point which is a tissue wrapped by a hard tissue, and said target point is located in said interested region, and wherein said fixture fixes said interested region;

using said computer unit to retrieve an image of said interested region of said individual, wherein said image is obtained with an MRI (Magnetic Resonance Imaging) technology or a CT (Computed Tomography) technology;

providing reference points on said interested region, wherein said reference points are located at spatial positions

using said computer unit to record said reference points on said interested region to determine coordinates of said reference points in said image of said interested region, and using said calibration tracker and said computer unit to track said tip of said dummy, said second tracking point and said first tracking point to search said spatial position of said focus point;

using said computer unit to compare said spatial positions of said first tracking point, said second tracking and said reference points with said coordinates of said first tracking point, said second tracking and said reference points in said image of said interested region to establish the positional relationship between said first tracking point, said second tracking point and said reference points in said image of said interested region, whereby said spatial position of said focus point corresponds to coordinates of said focus point in said image of said interested region based on known positional relationship between said second tracking point and said focus point;

guiding said focus point to said target point with said ultrasound system; and

delivering said energy to said target point with said focused ultrasound device.

13. The method according to claim 12, wherein said focused ultrasound energy is applied to cauterization, stimulating local or deep-seated cells, regulating local or deep-seated cells, enhancing blood vessel permeability, dissolving thrombi, and locally delivering medicine.

14. The method according to claim 12, wherein said focused ultrasound is applied to enhancing blood-to-brain permeability.

15. The method according to claim 12, further comprising a step of stopping output of said focused ultrasound energy when a subharmonic or a ultraharmonic accompanies an ultrasonic echo.

16. The method according to claim 12, wherein said focused ultrasound device is a multi-point focused ultrasound device.