Methods of treating depression and other related diseases

• US 10,167,314 B2
• Filed: 06/05/2017
• Issued: 01/01/2019
• Est. Priority Date: 10/05/2009
• Status: Active Grant

• Current Assignee: Northwestern University
• Original Assignee: Northwestern University
• Inventors: Moskal, Joseph R.
• Primary Examiner(s): Chernyshev, Olga N
• Application Number:
  US15/614,134
• Publication Number:
  US 20180094026A1
• Time in Patent Office: 575 Days
• Field of Search: None
• CPC Class Codes: A61K 38/07 Tetrapeptides
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 25/18 Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
• CPC Class Codes: A61P 25/22 Anxiolytics
• CPC Class Codes: A61P 25/24 Antidepressants
• CPC Class Codes: C07K 5/06139 with the first amino acid being heterocyclic
• CPC Class Codes: C07K 5/081 the side chain containing O or S as heteroatoms, e.g. Cys, Ser
• CPC Class Codes: C07K 5/0821 with the first amino acid being heterocyclic, e.g. His, Pro, Trp
• CPC Class Codes: C07K 5/1013 the side chain containing O or S as heteroatoms, e.g. Cys, Ser

Abstract

The invention relates to methods for treating depression, anxiety, and other related diseases by administering a peptide NMDAR partial agonist.

Claims

1. A method for treating a patient suffering from postpartum depression comprising administering to said patient an effective amount of a GLYX-13 peptide represented by formula:

2. A method for treating a patient suffering from a post-traumatic stress disorder comprising administering to said patient an effective amount of a GLYX-13 peptide represented by formula:

3. A method for treating a patient suffering from a depression comprising administering to said patient an effective amount of a GLYX-13 peptide represented by formula:

4. The method according to claim 3 wherein said patient is at risk of suicide.

5. The method according to claim 3 wherein said patient experiences or exhibits symptoms of depression selected from hopelessness, self-harm or suicide, an absence of positive thoughts or plans, or a combination thereof.