Medical devices having activated surfaces

• US 10,167,371 B2
• Filed: 11/03/2016
• Issued: 01/01/2019
• Est. Priority Date: 02/21/2009
• Status: Active Grant

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Covidien LP (Medtronic Plc)
• Inventors: Belcheva, Nadya, Abuzaina, Ferass, Elachchabi, Amin, Kapiamba, Mbiya, Hadba, Ahmad Robert
• Primary Examiner(s): Yoon, Tae H
• Application Number:
  US15/342,488
• Publication Number:
  US 20170073486A1
• Time in Patent Office: 789 Days
• Field of Search: 428357, 523105, 523205, 523112, 523113
• CPC Class Codes: A61L 2400/18 Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
• CPC Class Codes: A61L 31/04 Macromolecular materials
• CPC Class Codes: A61L 31/042 Polysaccharides
• CPC Class Codes: A61L 31/043 Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61L 31/044 Collagen
• CPC Class Codes: A61L 31/048 obtained by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61L 33/06 Use of macromolecular materials grafting of a monomer onto the substrate A61L33/0088
• CPC Class Codes: C08J 2300/16 Biodegradable polymers
• CPC Class Codes: C08J 7/12 Chemical modification
• CPC Class Codes: C08J 7/14 with acids, their salts or anhydrides
• CPC Class Codes: Y10T 442/20 Coated or impregnated woven, knit, or nonwoven fabric which is not [a] associated with another preformed layer or fiber layer or, [b] with respect to woven and knit, characterized, respectively, by a particular or differential weave or knit, wherein the coating or impregnation is neither a foamed material nor a free metal or alloy layer

Abstract

Implantable biocompatible polymeric medical devices include a substrate with an acid or base-modified surface which is subsequently modified to include click reactive members.

Claims

1. A polymeric medical device having an acid or base-treated surface that is functionalized with one or more click reactive members to provide an activated surface on the polymeric medical device.

2. The medical device of claim 1, wherein the medical device comprises a biodegradable polymer selected from collagen, cellulose, poly (amino acids), polysaccharides, hyaluronic acid, copolymers and combinations thereof.

3. The medical device of claim 1, wherein the medical device comprises a non-degradable polymer selected from fluorinated polymers, polyolefins, nylons, polyamides, polyurethanes, silicones, ultra high molecular weight polyethylene, polybutesters, polyaryletherketone, copolymers and combinations thereof.

4. The medical device of claim 1, wherein the one or more click reactive members are selected from the group consisting of thiols, azides, alkynes and alkenes.

5. The medical device of claim 1, wherein the one or more click reactive members comprise a thiol.

6. The medical device of claim 1, wherein the one or more click reactive members comprise an azide.

7. The medical device of claim 1, wherein the one or more click reactive members comprise an alkyne.

8. The medical device of claim 1, wherein the one or more click reactive members comprise an alkene.

9. The medical device of claim 1, wherein the medical device is selected from the group consisting of monofilament sutures, multifilament sutures, surgical meshes, ligatures, staples, slings, patches, foams, pellicles, films, barriers, stents, catheters, and inflatable balloons.

10. The medical device of claim 1, wherein the medical device comprises a surgical mesh.

11. The medical device of claim 1, wherein acid or base-treated surface is hydrolyzed prior to being functionalized with the at least one click-reactive member.

12. The medical device of claim 1, wherein the acid treated surface is treated with an acid selected from the group consisting of HCl, HCl₃, HCl₄, H₂SO₃, H₂SO₄, H₃PO₄, HI, HIO₃, HBr, lactic acid and glycolic acid.

13. The medical device of claim 1, wherein the base treated surface is treated with a base selected from the group consisting of LiOH, Ba(OH)₂, Mg(OH)₂, NaOH, KOH, Na₂CO₃, Ca(OH)₂, and NH₄OH.

14. The medical device of claim 1, further comprising a drug functionalized with one or more complementary click reactive members, wherein the one or more click reactive members of the medical device and the one or more complementary click reactive members of the drug interact to covalently bond the drug to the activated surface of the medical device.

15. The medical device of claim 14, wherein the one or more click reactive members comprise a thiol and the one or more complementary click reactive members comprise an alkene.

16. The medical device of claim 14, wherein the one or more click reactive members comprise an alkene and the one or more complementary click reactive members comprise a thiol.

17. The medical device of claim 14, wherein the one or more click reactive members comprise an alkyne and the one or more complementary click reactive members comprise an azide.

18. The medical device of claim 14, wherein the one or more click reactive members comprise an azide and the one or more complementary click reactive members comprise an alkyne.